130486-78-1Relevant academic research and scientific papers
75. Enantiomeric 3,7-Dimethylocta-1,7-dienes as Useful Chiral Building Blocks. A New Access to Both Optical Antipodes of Natural (E)-3,7-Dimethyloct-2-ene-1,8-diol and (E)-3,7-Dimethyloct-2-ene-1,8-dicarboxylic Acid
Giersch, Wolfgang,Schulte-Elte, Karl H.
, p. 733 - 738 (1990)
Ozonolysis of the easily available monoterpenoids (-)-1 and (+)-1 leads in high yield to the keto-aldehydes (-)-4 and (+)-4, which serve as convenient intermediates for efficient new routes to both optical antipodes of the naturally occuring octene-diol (E)-2 (Monarch butterfly secretion product) and octene-dicarboxylic acid (E)-3 (Callosobruchus chinensis sex pheromone).All steps proceed with almost complete retention of configuration, ensuring the synthesis of the target compounds with high optical purity.
Biocatalysis at Work: Applications in the Development of Sagopilone
Gottfried, Kathrin,Klar, Ulrich,Platzek, Johannes,Zorn, Ludwig
, p. 1240 - 1248 (2015/07/07)
For the antitumour agent sagopilone, an epothilone analogue, a large-scale synthesis was developed to synthesise the active pharmaceutical ingredient for clinical trials, exploring enzymatic and microbial methods to produce chiral building blocks on a mul
