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1305-78-8 Usage


Calcium oxide, also known as lime, quicklime, burnt lime, or calx, is an odorless, white or gray-white solid in the form of hard lumps. It is a strong irritant to skin, eyes, and mucous membranes. Calcium oxide is produced from calcium carbonate, limestone, or oyster shells by calcination at high temperatures. It is a caustic crystalline alkali substance with a very high affinity for water, reacting exothermically to form calcium hydroxide.


1. Used in Chemical Industry:
Calcium oxide is used as an analysis reagent and flux agent for manufacturing fluorescence powder. It is also used as an inexpensive alkali in the chemical industry and is widely used in pesticides, paper, food, petrochemical, and leather industries.
2. Used in Metallurgy:
Calcium oxide is used in the manufacture of calcium carbide, soda ash, and bleaching powder. It is also used as a metallurgical flux agent and for the removal of impurities during the refining of iron ore.
3. Used in Construction:
Calcium oxide is used as a building material, particularly in the production of bricks, plaster, mortar, stucco, and other construction materials. It is also used in the production of Portland cement, which is the basis for most mortars and concrete.
4. Used in Agriculture:
Calcium oxide is used as a soil conditioner and calcium fertilizer. It has a high neutralizing value and is used to neutralize acidic soils, improving soil structure and fertility.
5. Used in Water Treatment:
Calcium oxide is used in water and sewage treatment, as well as in the purification of metal refining processes. It is also used in the remediation of mine wastes to recover cyanides and neutralize acid mine drainage.
6. Used in Food Industry:
Calcium oxide is used as an anticaking agent, firming agent, and nutritive supplement in applications such as grain products and soft candy.
7. Used in Laboratory:
Calcium oxide is used for the drying of laboratory ammonia and alcohol dehydration.
8. Used in Drug Delivery Systems:
Calcium oxide can be used as drug carriers, enhancing the delivery, bioavailability, and therapeutic outcomes of various pharmaceuticals.
9. Used in Flotation of Minerals:
Lime, or calcium oxide, is the most widely used reagent in the mineral industry for the flotation of sulfides and, in some cases, non-sulfide minerals.
10. Used in Glass Manufacturing:
Calcium oxide is the principal flux in medium and high-temperature glazes, beginning its action within the glaze around 1100°C. It must be used with care in high-fire bodies due to its active fluxing action.

Content analysis

Approximately 1 g of the sample was burned to constant weight (accurately weighed) and dissolved in 20 ml of dilute hydrochloric acid solution (TS-117). After cooling, dilute to 500.0ml with water and mix uniformly. Take 50 mL of this solution into the appropriate container, add 50ml of water. Add 30 mL 0.05ml/L disodium EDTA via a 50 mL burette with stirring (preferably with a magnetic stirrer); further add 15ml sodium hydroxide solution (TS-224) and hydroxy naphthol blue indicator (300 mg) for continue titration to the blue end. Per ml of 0.05 mol/L of EDTA corresponds to 2.804 mg of calcium oxide.

Identification test

1 g of the sample was shaken with 20 ml of water, and the acetic acid test solution (TS-1) was added to dissolve the sample. The calcium test (IT-10) of this solution was positive.


ADI is not subject to restrictive regulations (FAO/WHO, 2001). GRAS (FDA, §18.5210; §184.12l0, 2000); See Calcium Oxide. It can stimulate the mucous membrane, causing sneezing, in particular, can cause fat saponification so the water will be absorbed by the skin, dissolving the protein with stimulating and corroding the tissue. It has strong effect against the eye mucosa, being able cause oral and nasal mucosa superficial ulcers, and sometimes there may be perforation of the nasopharyngeal diaphragm, deep respiratory tract disease. Inhalation of lime dust may cause pneumonia. In case of inhalation of dust, it can be treated via inhaling water vapor (add some of the citric acid crystals to the water in advance) and coat the mustard cream in the chest. If falling into the eyes, we can open up the eyes and immediately rinse with running water for 10~30 min and then rinse with 5% ammonium chloride solution. When the skin burns, it can be used with 5% citric acid, tartaric acid, acetic acid or salt solution of mineral oil or vegetable oil to remove the lime residue sticking to the skin. The maximum allowable concentration in the United States is 5 mg/m3. During operation, it should be paid attention to the protection of respiratory organs. Wear uniforms manufactured using dust-proof fiber, gloves and closed dust-proof glasses. Coat the ointment-containing grease. Clean after work. During the preparation and application, it should be prevented of dust inhalation.

Production method

Calcium carbonate calcination first apply calcium carbonate for reaction with hydrochloric acid to generate calcium chloride, followed by addition of ammonia for neutralization, standing for precipitation and filtration, followed by adding sodium bicarbonate for reaction to generate calcium carbonate precipitate. It is further subject to centrifugal separation dehydration, drying and calcination, followed by crushing and screening to obtain the finished product of medicinal calcium oxide. Its reaction is: CaCO3 + 2HCl → CaCl2 + CO2 + H2O CaCl2 + 2NH3? H2O? Ca (OH) 2 + 2NH4Cl Ca (OH) 2 + NaHCO3 → CaCO3 + NaOH + H2O CaCO3 [△]→CaO + CO2 ?. Limestone calcination method: crush the coarse limestone to 150 mm, and screen for the fine residue below 30 to 50 mm. Anthracite or coke required a particle size to be below 50 mm, which contains not too much low melting point ash content. The amount of anthracite or coke is 7.5% to 8.5% of that of limestone by weight. The selected limestone and fuel are timely and quantitatively supplied from the kiln crown to the kiln, further calcinated at 900~1200 ℃ and then lead to the finished product after cooling. In the calcination process, carbon dioxide is produced as by-product. Its reaction equation is: CaCO3 [△]→CaO + CO2 .

Usage limitation

GB 14880-94 (in terms of Ca, g/kg): beverages, cereals and their products, 1.6~3.2; infant food, 3.0~6.0. GB 2760-2001: Preparation of water 100mg/L (36mg/L in terms of Ca).

Hazards & Safety Information

Category Corrosive items Toxic classification poisoning Acute toxicity Intraperitoneal-mouse LD50: 3059 mg/kg Explosive and hazardous properties it is corrosive to the skin; powdered calcium oxide can be mixed with water to be explode; its mixture with alcohol can be flammable and explosive upon heating Flammable hazardous characteristics exothermic upon water with its heat being able to cause organic combustion; one of the air pollutants with heating together with alcohol mixture being able to cause combustion Storage and transportation characteristics Treasury: Ventilated, low temperature and drying; Store separately from combustible materials, acids and phosphorus pentoxide. Fire extinguishing agent mist water, sand Occupational Standard TLV-TWA 2 mg/m3; STEL 5 mg/m3


Calcium oxide dates from prehistoric times. It is produced by heating limestone to drive off carbon dioxide in a process called calcination: CaCO3(s) CaO(s) + CO2(g). At temperatures of several hundred degrees Celsius, the reaction is reversible and calcium oxide will react with atmospheric carbon dioxide to produce calcium carbonate. Efficient calcium oxide production is favored at temperatures in excess of 1,000°C. In prehistoric times limestone was heated in open fires to produce lime. Over time, lined pits and kilns were used to produce lime. Brick lime kilns were extensively built starting in the 17th century and the technology to produce lime has remained relatively constant since then.

Production Methods

Calcium oxide is commercially obtained from limestone. The carbonate is roasted in a shaft or rotary kiln at temperatures below 1,200°C until all CO2 is driven off. The compound is obtained as either technical, refractory or agri cultural grade product. The commercial product usually contains 90 to 95% free CaO. The impurities are mostly calcium carbonate, magnesium carbon ate, magnesium oxide, iron oxide and aluminum oxide.

Air & Water Reactions

Crumbles on exposure to moist air. Reacts with water to form corrosive calcium hydroxide, with evolution of much heat. Temperatures as high as 800° C have been reached with addition of water (moisture in air or soil). The heat of this reaction has caused ignition of neighboring quantities of sulfur, gunpowder, wood, and straw [Mellor 3: 673 1946-47].

Reactivity Profile

A base and an oxidizing agent. Neutralizes acids with generation of heat. Nonflammable, but will support combustion by liberation of oxygen, especially in the presence of organic materials. Reacts very violently with liquid hydrofluoric acid [Mellor 2, Supp. 1:129 1956]. Reacts extremely violently with phosphorus pentaoxide when reaction is initiated by local heating [Mellor 8 Supp.3:406 1971].


Evolves heat on exposure to water. Danger- ous near organic materials. Upper respiratory tract irritant.

Health Hazard

Causes burns on mucous membrane and skin. Inhalation of dust causes sneezing.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Vapors may accumulate in confined areas (basement, tanks, hopper/tank cars etc.). Substance will react with water (some violently), releasing corrosive and/or toxic gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Flammability and Explosibility


Safety Profile

A caustic and irritating material. See also CALCIUM COMPOUNDS. A common air contaminant. A powerful caustic to living tissue. The powdered oxide may react explosively with water. Mixtures with ethanol may igmte if heated and thus can cause an air-vapor explosion. Violent reaction with (I3203 + CaCl2) interhalogens (e.g., BF3, CIF3), F2, HF, P2O5 + heat, water. Incandescent reaction with liquid HF. Incompatible with phosphoms(V) oxide.

Potential Exposure

Calcium oxide is used as a refractory material; a binding agent in bricks; plaster, mortar, stucco, and other building materials. A dehydrating agent, a flux in steel manufacturing, and a labora


UN1910 Calcium oxide, Hazard class: 8; Labels: 8-Corrosive material.


The water solution is a medium strong base. Reacts with water, forming calcium hydroxide and sufficient heat to ignite nearby combustible materials. Reacts violently with acids, halogens, metals.

Waste Disposal

Pretreatment involves neutralization with hydrochloric acid to yield calcium chloride. The calcium chloride formed is treated with soda ash to yield the insoluble calcium carbonate. The remaining brine solution may be discharged into sewers and waterways

Check Digit Verification of cas no

The CAS Registry Mumber 1305-78-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,3,0 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1305-78:
58 % 10 = 8
So 1305-78-8 is a valid CAS Registry Number.

1305-78-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (10684)  Calcium oxide, Puratronic?, 99.998% (metals basis, excluding other alkaline earth and alkali metals 130ppm max)   

  • 1305-78-8

  • 2g

  • 238.0CNY

  • Detail
  • Alfa Aesar

  • (10684)  Calcium oxide, Puratronic?, 99.998% (metals basis, excluding other alkaline earth and alkali metals 130ppm max)   

  • 1305-78-8

  • 10g

  • 1010.0CNY

  • Detail
  • Alfa Aesar

  • (10684)  Calcium oxide, Puratronic?, 99.998% (metals basis, excluding other alkaline earth and alkali metals 130ppm max)   

  • 1305-78-8

  • 50g

  • 4909.0CNY

  • Detail
  • Alfa Aesar

  • (10684)  Calcium oxide, Puratronic?, 99.998% (metals basis, excluding other alkaline earth and alkali metals 130ppm max)   

  • 1305-78-8

  • 250g

  • 20880.0CNY

  • Detail
  • Alfa Aesar

  • (44776)  Calcium oxide, 99.95% (metals basis)   

  • 1305-78-8

  • 50g

  • 450.0CNY

  • Detail
  • Alfa Aesar

  • (44776)  Calcium oxide, 99.95% (metals basis)   

  • 1305-78-8

  • 250g

  • 2090.0CNY

  • Detail
  • Alfa Aesar

  • (44776)  Calcium oxide, 99.95% (metals basis)   

  • 1305-78-8

  • 1kg

  • 8359.0CNY

  • Detail
  • Alfa Aesar

  • (10923)  Calcium oxide, 99.95% (metals basis)   

  • 1305-78-8

  • 50g

  • 395.0CNY

  • Detail
  • Alfa Aesar

  • (10923)  Calcium oxide, 99.95% (metals basis)   

  • 1305-78-8

  • 250g

  • 1783.0CNY

  • Detail
  • Alfa Aesar

  • (10923)  Calcium oxide, 99.95% (metals basis)   

  • 1305-78-8

  • 1kg

  • 5710.0CNY

  • Detail
  • Alfa Aesar

  • (33299)  Calcium oxide, Reagent Grade   

  • 1305-78-8

  • 500g

  • 791.0CNY

  • Detail
  • Alfa Aesar

  • (33299)  Calcium oxide, Reagent Grade   

  • 1305-78-8

  • 2kg

  • 2431.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name calcium oxide

1.2 Other means of identification

Product number -
Other names Lime,Quicklime

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1305-78-8 SDS

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1305-78-8Related news

Efficacy of newly developed nano-crystalline Calcium oxide (cas 1305-78-8) catalyst for biodiesel production08/13/2019

The present work proposes the synthesis of nanocrystalline calcium oxide by sonication assisted reverse emulsion technique. The synthesized and the commercially available calcium oxide were characterized by various techniques. The prepared material possesses 1.53 times higher specific surface ar...detailed

Interaction of calcium phosphates with Calcium oxide (cas 1305-78-8) or calcium hydroxide during the “soft” mechanochemical synthesis of hydroxyapatite08/11/2019

In the present work, the formation kinetics of hydroxyapatite Ca10(PO4)6(OH)2 during ball milling of mixtures of calcium phosphates with calcium oxide or calcium hydroxide was studied. The conversion degrees of reaction mixtures containing calcium dihydrogenphosphate/dicalcium phosphate/tricalci...detailed

Study on effectiveness of activated Calcium oxide (cas 1305-78-8) in pilot plant biodiesel production08/10/2019

One of the main problems in large-scale biodiesel production is selection of suitable and economically viable heterogenous catalyst. This research work focuses on preparation of calcium oxide (CaO) as a catalyst for the effective conversion of waste cooking oil (WCO) to biodiesel in pilot plant....detailed

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