130506-04-6Relevant articles and documents
THE BIRCH REDUCTION/ALKYLATION OF PHTHALIDES THE SYNTHESIS OF SOME SUBSTITUTED BICYCLOOCTANES
Box, Vernon G.S.,Yiannikouros, George P.
, p. 971 - 976 (2007/10/02)
The first successful reductions of the aromatic rings of phthalides, with the preservation of the lactone rings, are reported.The reduction/alkylation of some substituted 4-methoxyphthalides gave lactonic enol ethers, which were converted into conjugated homocyclic dienes and further into cyclohexanones.These enones were easily converted into bicyclooctanes by Bu3SnH/AIBN free radical cyclization reaction.