130518-09-1

Basic information

• Product Name: Hydrazinecarboxylic acid, 2-(2-methoxy-2-oxoethyl)-, 1,1-dimethylethyl ester
• Synonyms: Hydrazinecarboxylic acid, 2-(2-methoxy-2-oxoethyl)-, 1,1-dimethylethyl ester
• CAS NO: 130518-09-1
• Molecular Formula: C₈H₁₆N₂O₄
• Molecular Weight: 204.22364
• Product Categories: N-BOC
• Mol File: 130518-09-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Hydrazinecarboxylic acid, 2-(2-methoxy-2-oxoethyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarboxylic acid, 2-(2-methoxy-2-oxoethyl)-, 1,1-dimethylethyl ester(130518-09-1)
• EPA Substance Registry System: Hydrazinecarboxylic acid, 2-(2-methoxy-2-oxoethyl)-, 1,1-dimethylethyl ester(130518-09-1)

Safety Data

• Hazardous Substances Data: 130518-09-1(Hazardous Substances Data)

Upstream product

• 922-68-9 Methyl glyoxylate 
• 870-46-2 t-butoxycarbonylhydrazine 
• 96-34-4 methyl chloroacetate 
• 96-32-2 bromoacetic acid methyl ester 
• 96-35-5 glycolic acid methyl ester 
• 102831-44-7 diethyl tert-butoxycarbonylaminomalonate 
• 68014-21-1 triphenyl(t-butoxycarbonylimino)phosphorane 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 462100-44-3 oxaziridine-2,3,3-tricarboxylic acid 2-tert-butyl ester 3,3-diethyl ester 
• 105838-14-0 tert-butyl N-tosyloxycarbamate 

Downstream Products

• 949147-54-0 Boc-aza-β³-Asn-OBn 

Relevant articles and documents

Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates**

Antibody–drug conjugates (ADCs) are a new class of therapeutics that combine the lethality of potent cytotoxic drugs with the targeting ability of antibodies to selectively deliver drugs to cancer cells. In this study we show for the first time the synthesis of a reactive-oxygen-species (ROS)-responsive ADC (VL-DAB31-SN-38) that is highly selective and cytotoxic to B-cell lymphoma (CLBL-1 cell line, IC50 value of 54.1 nM). The synthesis of this ADC was possible due to the discovery that diazaborines (DABs) are a very effective ROS-responsive unit that are also very stable in buffer and in plasma. DFT calculations performed on this system revealed a favorable energetic profile (ΔGR=?74.3 kcal mol?1) similar to the oxidation mechanism of aromatic boronic acids. DABs’ very fast formation rate and modularity enabled the construction of different ROS-responsive linkers featuring self-immolative modules, bioorthogonal functions, and bioconjugation handles. These structures were used in the site-selective functionalization of a VL antibody domain and in the construction of the homogeneous ADC.

N-amination of amino acids and its derivatives using N-Boc-O-tosyl hydroxylamine as an efficient NH-Boc transfer reagent: Electrophilic amination

Terminal tert-butyloxycarbonyl (Boc) protected hydrazino acids, useful intermediates for modified peptides and biologically active heterocyclic derivatives, were synthesized by electrophilic amination methodology using N-Boc-O-tosyl hydroxylamine as an ef

Preparation of new monomers aza-β3-aminoacids for solid-phase syntheses of aza-β3-peptides

The preparation of new Nβ-Fmoc-protected aza-β3-amino acids (aza-β3-aa) with proteinogenic side chains as well as their Nβ-Fmoc, Nβ-Cbz or Nβ-Boc aza-β3-amino esters (from Pro, Asn, Asp, Glu, Gln) by successive nucleophilic substitutions will be described.