130521-20-9

Basic information

• Product Name: 1-Propanone, 1-(3-amino-4-hydroxyphenyl)-
• CAS NO: 130521-20-9
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Mol File: 130521-20-9.mol

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(3-amino-4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(3-amino-4-hydroxyphenyl)-(130521-20-9)
• EPA Substance Registry System: 1-Propanone, 1-(3-amino-4-hydroxyphenyl)-(130521-20-9)

Safety Data

• Hazardous Substances Data: 130521-20-9(Hazardous Substances Data)

Usage

Class

Ketones and phenylhydrazones

Appearance

Off-white to yellow crystalline solid

Molecular weight

189.204 g/mol

Uses

Synthesis of various pharmaceutical compounds and as a building block for the production of other organic molecules

Safety precautions

Can cause irritation to the skin, eyes, and respiratory system upon contact or inhalation

Upstream product

• 50916-44-4 1-(4-hydroxy-3-nitrophenyl)propan-1-one 
• 130521-17-4 N-(2-Hydroxy-5-propionyl-phenyl)-acetamide 
• 614-80-2 2-(acetylamino)phenol 
• 70-70-2 4-hydroxypropiophenone 

Downstream Products

• 112018-01-6 bemoradan 
• 141244-22-6 3'-(3-ethylureido)-4'-hydroxypropiophenone 
• 149647-04-1 1-(2-Hydroxy-5-propionyl-phenyl)-3-methyl-urea 

Relevant articles and documents

Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of duchenne muscular dystrophy

Figure Presented. A series of novel 2-arylbenzoxazoles that upregulate the production of utrophin in murine H2K cells, as assessed using a luciferase reporter linked assay, have been identified. This compound class appears to hold considerable promise as a potential treatment for Duchenne muscular dystrophy. Following the delineation of structure-activity relationships in the series, a number of potent upregulators were identified, and preliminary ADME evaluation is described. These studies have resulted in the identification of 1, a compound that has been progressed to clinical trials.

Studies on antiulcar drugs. II. Synthesis and antiulcer activities of imidazo[1,2-a]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-tetrahydroimidazo[1,2-a]pyridinyl derivatives

A series of imidazo[1,2-a]pyridinylbenzoxazoles (4) and 5,6,7,8-tetrahydroimidazo[1,2-a]pyridinylbenzoxazoles (5) were synthesized and tested for anti-stress ulcer activity in rats. Several compounds were found to be more active than the reference compoun

Unequivocal Preparation of 4- and 5-Acyl-2-aminophenols

Unequivocal methods for the specific preparation of 4- or 5-acyl-2-aminophenols are reported. 5-Acyl-2-aminophenols are obtained by ring opening with dilute sodium hydroxide of 2(3H)-benzoxazolinones acylated at position 6. 4-Acyl-2-aminophenols are obtai