1305320-66-4

Basic information

• Product Name: 5-(4-Chlorophenyl)-4-(3-iodophenyl)-1,2-dimethylpyrrole-3-carboxylic Acid
• Synonyms: 5-(4-Chlorophenyl)-4-(3-iodophenyl)-1,2-dimethylpyrrole-3-carboxylic Acid
• CAS NO: 1305320-66-4
• Molecular Formula: C₁₉H₁₅ClINO₂
• Molecular Weight: 451.68537
• Mol File: 1305320-66-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-Chlorophenyl)-4-(3-iodophenyl)-1,2-dimethylpyrrole-3-carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Chlorophenyl)-4-(3-iodophenyl)-1,2-dimethylpyrrole-3-carboxylic Acid(1305320-66-4)
• EPA Substance Registry System: 5-(4-Chlorophenyl)-4-(3-iodophenyl)-1,2-dimethylpyrrole-3-carboxylic Acid(1305320-66-4)

Safety Data

• Hazardous Substances Data: 1305320-66-4(Hazardous Substances Data)

Usage

Molecular structure

Contains a pyrrole ring with two methyl groups at positions 1 and 2, and a carboxylic acid functionality at position 3

Substituents

4-chlorophenyl group at position 5 and 3-iodophenyl group at position 4

Highly substituted compound

Due to the presence of multiple substituents

Potential applications

Potential biological or pharmaceutical applications due to its structural features and potential interactions with other molecules or biological systems. Further studies and research may be required for a better understanding of its properties and potential uses.

Upstream product

• 696-41-3 m-iodobenzaldehyde 
• 1384513-08-9 ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-1-isopropyl-2-methyl-1H-pyrrole-3-carboxylate 
• 1384513-05-6 ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate 
• 1384513-06-7 ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carboxylate 

Downstream Products

• 1384513-18-1 5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1,2-dimethyl-1H-pyrrole-3-carboxylic acid 
• 1384512-98-4 (R)-5-(4-chlorophenyl)-4-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1,2-dimethyl-1H-pyrrole-3-carboxylic acid 
• 1384512-97-3 (R)-5-(4-chlorophenyl)-4-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)-phenyl)piperazin-1-yl)phenyl)-N,1,2-trimethyl-1H-pyrrole-3-carboxamide 
• 1384512-99-5 (R)-N-(4-(4-(3-(2-(4-chlorophenyl)-1,5-dimethyl-1H-pyrrol-3-yl)phenyl)piperazin-1-yl)phenyl)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrobenzenesulfonamide 
• 1384513-14-7 5-(4-chlorophenyl)-1,2-dimethyl-4-(3-(4-(4-nitrophenyl)-piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid 
• 1391108-32-9 5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carbonitrile 
• 1391108-30-7 3-chloro-5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole 
• 1391108-29-4 2-(4-chlorophenyl)-3-(3-iodophenyl)-1,5-dimethyl-1H-pyrrole 
• 1428145-89-4 5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-N-(methylsulfonyl)-1H-pyrrole-3-carboxamide 
• 1391108-31-8 5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carboxamide 
• 1391106-77-6 C₄₇H₄₉ClN₈O₄S₂ 
• 1391106-70-9 C₄₆H₄₉Cl₂N₇O₄S₂ 
• 1428146-21-7 C₃₆H₃₄ClFN₆O₇S₂ 
• 1391106-99-2 C₄₈H₅₃ClN₈O₇S₃ 

Relevant articles and documents

A potent and highly efficacious Bcl-2/Bcl-xL inhibitor

Our previously reported Bcl-2/Bcl-xL inhibitor, 4, effectively inhibited tumor growth but failed to achieve complete regression in vivo. We have now performed extensive modifications on its pyrrole core structure, which has culminated in the discovery of 32 (BM-1074). Compound 32 binds to Bcl-2 and Bcl-xL proteins with Ki values of 50 values of 1-2 nM in four small-cell lung cancer cell lines sensitive to potent and specific Bcl-2/Bcl-xL inhibitors. Compound 32 is capable of achieving rapid, complete, and durable tumor regression in vivo at a well-tolerated dose schedule. Compound 32 is the most potent and efficacious Bcl-2/Bcl-xL inhibitor reported to date.