130539-83-2Relevant academic research and scientific papers
A new route to secondary amines from bis-(alkoxymethyl)-alkylamines - The activation of an aminomethyl group and protection of the product by the same functional group
Earle, Martyn J.,Fairhurst, Robin A.,Heaney, Harry,Papageorgiou, George,Wilkins, Robert F.
, p. 4229 - 4232 (2007/10/02)
Treatment of N,N-bis(alkoxymethyl)alkylamines with a variety of acidic reagents affords good yields of N-alkoxymethyl-N-alkylmethyleneiminium salts which react with trimethylsilyl enol ethers, and nucleophilic aromatic substrates to form protected secondary amines or tertiary amines by domino reactions; silyl ketene acetals afford tertiary amines only.
