130545-04-9Relevant academic research and scientific papers
2-Substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: Synthesis and biological activity
Stanek,Frei,Mett,Schneider,Regenass
, p. 1339 - 1344 (1992)
1-Amino-3-(aminooxy)-2-propanol (6a) has been synthesized and found to inhibit rat liver ornithine decarboxylase (ODC) with an IC50 in the nanomolar range. Compound 6a served as a basis for the design of new enzyme inhibitors, which led to the identification of 3-(aminooxy)-2- fluoropropanamine (15) as a new powerful enzyme blocker. Compound 15 inhibited ODC at 3 times lower concentrations than 6a and 3- (aminooxy)propanamine (APA), and it was superior to APA as an antiproliferative agent in inhibiting the growth of human T24 bladder carcinoma cells in vitro.
Hydroxylamine compounds
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, (2008/06/13)
Compounds of formula STR1 wherein R1 is amino or is a radical STR2 wherein R3 is lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, carboxy, lower alkoxycarbonyl, phenyl, phenyl substituted by lower alkyl, halo-lower alkyl,
