130548-06-0

Basic information

• Product Name: 2(3H)-Thiophenone,3-aminodihydro-, (3R)-
• Synonyms: 2(3H)-Thiophenone,3-aminodihydro-, (R)-; (R)-3-Aminodihydro-2(3H)-thiophenone; (R)-Homocysteinethiolactone; D-Homocysteine thiolactone
• CAS NO: 130548-06-0
• Molecular Formula: C₄H₇NOS
• Molecular Weight: 117.17
• Mol File: 130548-06-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(3H)-Thiophenone,3-aminodihydro-, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Thiophenone,3-aminodihydro-, (3R)-(130548-06-0)
• EPA Substance Registry System: 2(3H)-Thiophenone,3-aminodihydro-, (3R)-(130548-06-0)

Safety Data

• Hazardous Substances Data: 130548-06-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2(3H)-Thiophenone,3-aminodihydro-, (3R)is utilized as a building block in organic synthesis for the creation of complex organic molecules. Its unique structure, including the thiophenone and amine groups, allows for versatile chemical reactions, facilitating the synthesis of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2(3H)-Thiophenone,3-aminodihydro-, (3R)is employed as a precursor in the development of new drugs. 2(3H)-Thiophenone,3-aminodihydro-, (3R)-'s thiophenone and amine functionalities are commonly found in pharmacologically active molecules, making it a valuable component in the design and synthesis of potential therapeutic agents.
Further research and investigation are required to fully explore the potential uses and properties of 2(3H)-Thiophenone,3-aminodihydro-, (3R)-, as its applications may extend beyond the current understanding. Its unique structural features and stereochemistry could offer novel opportunities in both organic synthesis and pharmaceutical research.

Upstream product

• 13073-47-7 S-benzyl-D-homocysteine 
• 62965-24-6 (S-tert-butyl)-homocysteine 
• 454-28-4 D-homocysteine 
• 7689-60-3 S-benzyl-L-homocysteine 
• 59-51-8 DL-methionine 

Downstream Products

• 39837-08-6 N-(2-oxo-tetrahydro-thiophen-3-yl)-butyramide 
• 89807-04-5 D-[S-methyl-11C]methionine 
• 60305-58-0 L-[S-methyl-11C]methionine 
• 202284-85-3 (S)-N-butyryl homocysteine thiolactone 
• 6027-13-0 L-homocysteine 

Relevant articles and documents

Cyclization mechanism catalyzed by an ATP-grasp enzyme essential for d-cycloserine biosynthesis

In the biosynthetic pathway of an antitubercular antibiotic d-cycloserine (d-CS), O-ureido-d-serine (d-OUS) is converted to d-CS. We have previously demonstrated that DcsG, classified into the ATP-grasp superfamily enzyme, catalyzes the ring formation to generate d-CS, which is accompanied by the cleavage of a bond in the urea moiety of d-OUS to remove a carbamoyl group. Although the general ATP-grasp enzymes catalyze an ATP-dependent ligation reaction between two substrates, DcsG catalyzes specifically the generation of an intramolecular covalent bond. In the present study, cyanate was found in the reaction mixture, suggesting that carbamoyl group is eliminated as an isocyanic acid during the reaction. By the crystallographic and mutational investigations of DcsG, we anticipate the residues necessary for the binding of d-OUS. An acylphosphate intermediate must be bound at the narrow pocket of DcsG in a folded conformation, inducing the bond cleavage and the new bond formation to generate cyanate and d-CS, respectively. Database: Structural data are available in Protein Data Bank database under the accession number 6JIL.

Immonological detection of the homocystamide adduct and a thiolactone immunoassay for endogeneous homocysteine

An antibody specific for homocystamide adducts is disclosed. In a preferred embodiment of the present invention, the antibody is used to evaluate the level of homocysteine in a biological sample.