13057-73-3Relevant academic research and scientific papers
Ipriflavone preparation process
-
, (2008/06/13)
Process for the preparation of ipriflavone consisting in the following steps: a) reaction of 2,4-dihydroxy-phenyl-benzyl-ketone of formula (II) with ethyl orthoformate in dimethylformamide as solvent and in the presence of a catalyst consisting of morpholine, to yield 7-hydroxyisoflavone of formula (III), b) separation of product (III) from the reaction residue, c) alkylation of product (III) from step b) with isopropyl halide to obtain ipriflavone, wherein: I. step a) is carried out at a temperature ranging from 115 to 120° C. using a 2,4-dihydroxy-phenyl-benzyl-ketone (II) weight/solvent volume (w/v) ratio lower than 1:4; II. step b) consists in the precipitation of the corresponding salt with dicyclohexylamine of formula (IV). The process yields 7-hydroxyisoflavone (III) in high yields within short reaction times (2 h max.) and ipriflavone with impurity ≤0.1%. STR1
Ground mixture
-
, (2008/06/13)
A ground mixture of a poorly soluble crystalline drug and an adsorbent is remarkably improved in the rates of dissolution and adsorption of the drug.
Animal feed containing anabolic isoflavones
-
, (2008/06/13)
An animal feed containing 0.00002 to 0.1% by weight of: 2-methyl-7-methoxy-4'-nitroisoflavone, 7-[hydroxyethoxy]-2-methylisoflavone, 7-carbethoxy-2-methylisoflavone, 7-ethoxyisoflavone, 7-n-benzyloxy-2-methylisoflavone, 7-p-nitrobenzyloxyisoflavone, 7-p-nitrobenzyloxy-2-methylisoflavone, 7-p-chlorobenzyloxyisoflavone, 7-cetyloxy-2-methylisoflavone, 7-(2-octyloxy)-isoflavone, 7-benzyloxy-3',4'-dimethoxyisoflavone, and 7-hexadecyloxyisoflavone As a weight-gain promoting anabolic ingredient.
