130574-55-9Relevant academic research and scientific papers
Synthesis of Carboranyl Phenylalanine for Potential Use in Neutron Capture Therapy of Melanoma
Prashar, Jognandan K.,Moore, Douglas E.
, p. 1051 - 1054 (2007/10/02)
A phenylalanine derivative incorporating the 1,2-dicarba-closo-dodecaborane (12) cage has been synthesised by the alkylation of diethyl formamidomalonate with benzyl bromide in the presence of sodium ethoxide followed by the removal of the protecting groups by hydrolysis and decarboxylation.The closo-carborane species was converted into the anionic nido-form to produce a more water-soluble form of the compound.
