130609-48-2Relevant articles and documents
Expeditious synthesis of ramipril: An angiotensin converting enzyme (ACE) inhibitor
Malakondaiah, Golla China,Gurav,Reddy, Lekkala Amarnath,Babu, Karrothu Srihari,Bhaskar, Bolugoddu Vijaya,Reddy, Padi Pratap,Bhattacharya, Apurba,Anand, Ramasamy Vijaya
, p. 1737 - 1744 (2008/09/21)
We document an efficient and cost-effective synthesis of ramipril 1 utilizing (i) an environmentally benign process for the esterification of racemic 2-aza-bicyclo-[3.3.0]-octane-3-carboxylic acid hydrochloride 2 using boric acid as a catalyst and (ii) a robust resolution process for the synthesis of 3a by means of inexpensive and recyclable L-(+)-mandelic acid as key steps. Copyright Taylor & Francis Group, LLC.