130629-34-4

Upstream product

• 800366-89-6 2-(acetoxymethyl)acrylonitrile 
• 5575-51-9 tris(4-chlorophenyl)bismuthane 
• 2286-53-5 3-(4-chlorophenyl)-2-(hydroxymethyl)propanenitrile 
• 52906-62-4 3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester 

Relevant academic research and scientific papers

The Baylis-Hillman chemistry in aqueous media: A convenient synthesis of 2-methylenealkanoates and alkanenitriles

A convenient, general and efficient synthesis of 2-methylenealkanoates and alkanenitriles is accomplished via the regioselective nucleophilic (SN2′) addition of hydride ion from NaBH4 to (2Z)-2-(bromomethyl)alk-2-enoates and 2-(bromomethyl)alk-2-enenitriles respectively in the presence of DABCO in environment friendly aqueous media. Synthesis of two hypoglycemic agents is also described.

Pd-catalyzed threefold arylation of Baylis-Hillman bromides and acetates with triarylbismuth reagents

Functionalized alkyl 2-benzylacrylates and 2-benzylacrylonitriles were synthesized by means of atom-economic cross-couplings of Baylis-Hillman bromides or acetates with BiAr3 under palladium-catalyzed conditions. These reactions, involving thre

A Synthesis of 2-Alkyl and 2-Benzyl Substituted Acrylonitriles from 2-Alkyl and 2-Benzylidene Cyanoacetate Esters Under Mild Conditions

Substituted cyanoacetate esters were reduced with sodium borohydride to give good yields of the corresponding β-hydroxynitriles, which were converted to 2-substituted acrylonitriles by base catalysed elimination of their sulfonate esters.