130634-59-2

Upstream product

• 1849-36-1 para-nitrobenzenethiol 
• 109-64-8 1,3-dibromo-propane 

Downstream Products

• 143666-99-3 (3,4-Dimethoxy-benzyl)-methyl-[3-(4-nitro-phenylsulfanyl)-propyl]-amine 
• 143667-02-1 4-{3-[(3,4-Dimethoxy-benzyl)-methyl-amino]-propylsulfanyl}-phenylamine 

Relevant academic research and scientific papers

Synthesis and Activity against Multidrug Resistance in Chinese Hamster Ovary Cells of New Acridone-4-carboxamides

A number of tricyclic carboxamides have been synthesized and tested to evaluate their ability to reverse multidrug resistance in the CHRC/5 cell line.Among them the acridone derivatives were the most potent.A key feature is the presence of a dimethoxybenzyl or phenethylamine cationic site, separated from the tricyclic lipophilic part by a carbamoylphenyl chain.Optimization led to compounds 2 orders of magnitude more active than the prototype inhibitors verapamil and amiodarone.On the basis of in vitro and in vivo activities, 9,10-dihydro-5-methoxy-9-oxo-N-phenyl>-4-acridinecarboxamide (84) has been selected for further development.