130639-81-5

Basic information

• Product Name: (E)-3-[3,4-bis(tetrahydro-2H-pyran-2-yloxy)phenyl]-1-[2-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)phenyl]prop-2-en-1-one
• Synonyms: (E)-3-[3,4-bis(tetrahydro-2H-pyran-2-yloxy)phenyl]-1-[2-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)phenyl]prop-2-en-1-one
• CAS NO: 130639-81-5
• Molecular Weight: 524.611
• Mol File: 130639-81-5.mol

Chemical Properties

• CAS DataBase Reference: (E)-3-[3,4-bis(tetrahydro-2H-pyran-2-yloxy)phenyl]-1-[2-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)phenyl]prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-[3,4-bis(tetrahydro-2H-pyran-2-yloxy)phenyl]-1-[2-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)phenyl]prop-2-en-1-one(130639-81-5)
• EPA Substance Registry System: (E)-3-[3,4-bis(tetrahydro-2H-pyran-2-yloxy)phenyl]-1-[2-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)phenyl]prop-2-en-1-one(130639-81-5)

Safety Data

• Hazardous Substances Data: 130639-81-5(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 61854-89-5 3,4-di-[(tetrahydro-2H-pyran-2-yl)oxy]-benzaldehyde 
• 111841-07-7 2-hydroxy-4-(tetrahydropyran-2-yloxy)acetophenone 

Downstream Products

• 487-52-5 butein 

Relevant articles and documents

Synthesis, characterization, and antioxidant activity of Zn2+ and Cu2+ coordinated polyhydroxychalcone complexes

Four new metal complexes [Cu(ISO)2], [Cu(BUT)2] and [Zn(ISO)2], [Zn(BUT)2] of the polyhydroxychalcones (isoliquiritigenin and butein) are synthesized, structurally characterized and their antioxidant activity is investigated. The formation of the complexes [Cu(ISO)2] and [Zn(ISO)2] is followed by Job’s plot using NMR titration. The resulting compounds are characterized by mass spectrometry, IR spectroscopy, and elemental analysis. Studies on the radical scavenging activity are performed using DPPH as substrate. The results showed that the antioxidant activities of isoliquiritigenin and butein are enhanced after binding to copper or zinc. Graphical abstract: [Figure not available: see fulltext.]

Synthesis and activity of a new series of chalcones as aldose reductase inhibitors

A new series of chalcone derivatives has been synthesized and tested in vitro in order to assess their ability to inhibit aldose reductase enzyme (ALR2) and their specificity towards the target enzyme with respect to other oxidoreductases, such as aldehyde reductase, sorbitol dehydrogenase, and glutathione reductase. All the compounds display affinity for ALR2. The X-ray crystal structure of 1-(2,4-dihydroxyphenyl)-3-(2-methoxyphenyl)propen-1-one was determined.