13064-21-6

Basic information

• Product Name: hepta-1,6-dien-4-ylbenzene
• CAS NO: 13064-21-6
• Molecular Formula: C₁₃H₁₆
• Molecular Weight: 172.2661
• Mol File: 13064-21-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 230.6°C at 760 mmHg
• Flash Point: 87.2°C
• Density: 0.88g/cm³
• Vapor Pressure: 0.0991mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: hepta-1,6-dien-4-ylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: hepta-1,6-dien-4-ylbenzene(13064-21-6)
• EPA Substance Registry System: hepta-1,6-dien-4-ylbenzene(13064-21-6)

Safety Data

• Hazardous Substances Data: 13064-21-6(Hazardous Substances Data)

Usage

General Description

Hepta-1,6-dien-4-ylbenzene is a chemical compound consisting of a heptadiene chain attached to a benzene ring. hepta-1,6-dien-4-ylbenzene is commonly used in the synthesis of various organic compounds and serves as a valuable starting material in organic chemistry research. Hepta-1,6-dien-4-ylbenzene exhibits properties of both alkenes and aromatic compounds due to the presence of the double bonds in the heptadiene chain and the aromaticity of the benzene ring. Its unique structure makes it suitable for a variety of reactions, including Diels-Alder reactions and Friedel-Crafts reactions, making it a versatile building block for the production of a wide range of organic compounds.

Upstream product

• 100-52-7 benzaldehyde 
• 762-72-1 allyl-trimethyl-silane 
• 80735-94-0 1-Phenyl-3-buten-1-ol 
• 24850-33-7 allyltributylstanane 
• 134619-69-5 (1-bromobut-3-en-1-yl)benzene 
• 581-55-5 benzylidene 1,1-diacetate 
• 4392-24-9 3-bromo-1-phenyl-1-propenyl bromide 
• 80586-92-1 Allyl cinnamyl ether 
• 132587-07-6 1-phenylbut-3-enyl acetate 
• 53847-16-8 3-phenylhex-5-enal 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 139284-72-3 4-trimethylsiloxy-4-phenyl-1-butene 
• 33558-75-7 allyl(chloromethyl)dimethylsilane 

Downstream Products

• 7325-50-0 3-phenylpentanedial 
• 1338500-25-6 C₁₉H₁₈ClN₃O₂S₂ 
• 1338500-24-5 C₂₁H₁₉F₃N₄O₂S 
• 1338500-23-4 C₂₂H₂₀F₃N₃O₂S 
• 2448-19-3 C₂₁H₂₃NO 
• 39599-89-8 4-phenylcyclopentene 

Relevant articles and documents

Preparation of 4-arylcyclopentenes by sequential diallylation of arylaldehydes and ring-closing metathesis

Allylsilane diallylation of aryl aldehydes followed by ring closure metathesis leads to 4-arylcyclopentenes in good yields. Copyright Taylor & Francis, Inc.

Catalytic Performance of Al-MCM-41 Catalyst for the Allylation of Aromatic Aldehydes with Allyltrimethylsilane: Comparison with TiCl4 as Lewis acid

Mesoporous Al-MCM-41 molecular sieve with Si/Al ratio equal to 12.5 was synthesized under hydrothermal condition using cetyltrimithylammonium bromide (CTAB) as surfactant. This solid was characterized using several techniques e.g. powder X-ray diffraction (XRD), N2 adsorption-desorption, FT-IR, TG/DTG and pyridine adsorption-desorption followed by IR spectroscopy. The catalytic performance of Al-MCM-41 catalyst as Lewis acid was used without treatment and was compared with TiCl4 in the allylation of aromatic aldehydes with allyltrimethylsilane. The results showed that in presence of Al-MCM-41, homoallyl silyl ether is obtained regardless of the nature of aromatic aldehydes at a temperature of 35?°C. When TiCl4 was used, the reactions require temperature of ?85?°C and all the products obtained were due to the diallylation. To explain this different allylation in the presence of the Al-MCM-41 or TiCl4, two plausible reaction mechanisms are proposed. The Al-MCM-41 was used in four consecutive experiments without important loss of activity, confirming it stability. Finally, a new method for preparing single allylation in the short timeframe and mild conditions are presented.

Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors

The structure-activity relationship (SAR) of a novel, potent and metabolically stable series of sulfonamide-pyrazoles that attenuate β-amyloid peptide synthesis via γ-secretase inhibition is detailed herein. Sulfonamide-pyrazoles that are efficacious in reducing the cortical Aβx-40 levels in FVB mice via a single PO dose, as well as sulfonamide-pyrazoles that exhibit selectivity for inhibition of APP versus Notch processing by γ-secretase, are highlighted.