130652-83-4Relevant academic research and scientific papers
STEREOSPECIFIC APPROACH TO 3-OXOCEN-7-ONES VIA ALIPHATIC CLAISEN REARRANGEMENT. SYNTHESIS OF (+)-(2R,8S)- AND (+)-(2R,8R)-LAUTHISAN
Paquette, Leo A.,Sweeney, Thomas J.
, p. 4487 - 4502 (1990)
A general synthetic strategy based upon thermally-induced Claisen ring expansion as the pivotal step allows for rapid elaboration of the lauthisans in enantiomerically pure condition and proper absolute configuration.The short sequence (nine steps) constitutes a new and versatile route to naturally occurring medium-ring ethers.
