1306606-99-4Relevant academic research and scientific papers
Synthesis, anti-methicillin-resistant S. aureus (MRSA) evaluation, quantitative structure-activity relationship and molecular modeling studies of some novel bis-indoles as prospective MRSA pyruvate kinase
El Sayed, Inhibitors Mardia T.,Sabry, Nermien M.,Hamdy, Nehal A.,Voronkov, Andrey,Ogungbe, Ifedayo V.,Balakin, Konstantin,Abdel-Aziz, Mohamed S.
, p. 336 - 346 (2018/04/20)
Background: MRSA is a gram positive pathogen resistant to methicillin and other betalactam antibiotics, including penicillin, oxacillin, and declooxacillin. Statistical data suggest that as many as 19,000 people per year die from MRSA in the USA. Methods:
Anion binding and sensing properties of bis(3-indolyl)methene derivatives based on proton transfer process
Wang, Litao,He, Xiaoming,Guo, Yong,Xua, Jian,Shao, Shijun
experimental part, p. 60 - 65 (2012/04/18)
A series of the bis(3-indolyl)methene derivatives were synthesized and their anion binding and sensing properties in CH3CN or mixed CH 3CN/H2O solution have been investigated in detail by UV-vis spectroscopic techniques. The deprotonation/protonation of the bis(3-indolyl)methene receptor is responsible for the dramatic color and spectral changes. The introduction of the electron-donating or withdrawing group into different moiety of the bis(3- indolyl)methene skeleton, which tunes the acidity of the H-bond donor moiety or the basicity of the H-bond acceptor moiety, has a positive effect on the selectivity and sensitivity of such "proton-transfer" chemosensors for anions.
