1306607-31-7

Upstream product

• 951380-43-1 2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride 
• 1100905-46-1 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate 
• 178688-49-8 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one p-toluenesulfonate 
• 204205-33-4 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone 
• 100-88-9 cyclohexylsulfamic acid 
• 150322-43-3 prasugel 

Relevant academic research and scientific papers

NEW SALTS OF PRASUGREL AND A METHOD OF THEIR PRODUCTION

The invention relates to new pharmaceutically acceptable salts of the well-known substance reducing coagulation of blood, prasugrel of formula (I), which are characterized by high chemical stability, and a method of their production. The prasugrel salts a

METHOD OF PRODUCING HIGHLY PURE PRASUGREL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

A method for the production of 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]- 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate of formula (I) or its salts, characterized in that the compound of formula (III) in the form of a salt with an arene sulfonic acid is reacted with the compound of formula (XV), wherein Y means: chlorine, bromine, or an OR4 group, wherein R4 means an alkane sulfonic group or arene sulfonic group, in an organic solvent in the presence of an inorganic base or organic base, to give, after addition of an acetylating reagent and organic base to the reaction mixture, the compound of formula (I), which, after addition of a co-solvent, is crystallized from the reaction mixture, and the compound of formula (I) is optionally purified by crystallization and optionally converted to a salt by reaction with an organic or inorganic acid in a suitable solvent. (Formulae (I), (III), (XV)