1306684-76-3Relevant academic research and scientific papers
Inhibitors of Autotaxin
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Page/Page column 6, (2012/07/31)
Stabilized benzyl phosphonic acid and naphthyl phosphonic acid analog compounds are effective in inhibiting the activity of autotaxin.
Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity
Gupte, Renuka,Patil, Renukadevi,Liu, Jianxiong,Wang, Yaohong,Lee, Sue C.,Fujiwara, Yuko,Fells, James,Bolen, Alyssa L.,Emmons-Thompson, Karin,Yates, C. Ryan,Siddam, Anjaih,Panupinthu, Nattapon,Pham, Truc-Chi T.,Baker, Daniel L.,Parrill, Abby L.,Mills, Gordon B.,Tigyi, Gabor,Miller, Duane D.
experimental part, p. 922 - 935 (2012/01/06)
Autotaxin (ATX, NPP2) is a member of the nucleotide pyrophosphate phosphodiesterase enzyme family. ATX catalyzes the hydrolytic cleavage of lysophosphatidylcholine (LPC) by lysophospholipaseD activity, which leads to generation of the growth-factor-like l
