130669-86-2Relevant academic research and scientific papers
Carbonic anhydrase inhibitory properties of novel benzylsulfamides using molecular modeling and experimental studies
Goeksu, Sueleyman,Naderi, Ali,Akbaba, Yusuf,Kalin, Pinar,Akincioglu, Akin,Guelcin, Ilhami,Durdagi, Serdar,Salmas, Ramin Ekhteiari
, p. 75 - 82 (2014)
In this study, a series of sulfamoyl carbamates and sulfamide derivatives were synthesized. Six commercially available benzyl amines and BnOH were reacted with chlorosulfonyl isocyanate (CSI) to give sulfamoyl carbamates. Pd-C catalyzed hydrogenolysis rea
Carbonic anhydrase inhibitory properties of novel benzylsulfamides using molecular modeling and experimental studies
G?ksu, Süleyman,Naderi, Ali,Akbaba, Yusuf,Kalin, Pinar,Akinciolu, Akin,Gülin, Ilhami,Durdagi, Serdar,Salmas, Ramin Ekhteiari
, p. 75 - 82 (2014/12/11)
In this study, a series of sulfamoyl carbamates and sulfamide derivatives were synthesized. Six commercially available benzyl amines and BnOH were reacted with chlorosulfonyl isocyanate (CSI) to give sulfamoyl carbamates. Pd-C catalyzed hydrogenolysis reactions of carbamates afforded sulfamides. The inhibition effects of novel benzylsulfamides on the carbonic anhydrase I, and II isoenzymes (CA I, and CA II) purified from fresh human blood red cells were determined by Sepharose-4B-L-Tyrosine-sulfanilamide affinity chromatography. In vitro studies were shown that all of novel synthesized benzylsulfamide analogs inhibited, concentration dependently, both hCA isoenzyme activities. The novel benzylsulfamide compounds investigated here exhibited nanomolar inhibition constants against the two isoenzymes. Ki values were in the range of 28.48 ± 0.01-837.09 ± 0.19 nM and 112.01 ± 0.01-268.01 ± 0.22 nM for hCAI and hCA II isoenzymes, respectively. Molecular modeling approaches were also applied for studied compounds.
Intra- and Intermolecular α-Sulfamidoalkylation Reactions
Lee, Chai-Ho,Kohn, Harold
, p. 6098 - 6104 (2007/10/02)
The utility of α-sulfamidoalkylation processes for the generation of sulfamides has been examined.Select aryl-substituted sulfamides were prepared and then treated with acid.Both intra- and intermolecular α-sulfamidoalkylation transformations were observed to proceed in moderate to good yields.The pathways for these reactions are discussed.The generality of these processes has been demonstrated using N,N'-di(aryl-substituted)sulfamides, and the utility of these reactions was examined for the preparation of cyclic sulfamides of novel structure.
