1306753-76-3

Basic information

• Product Name: Ethyl 4-[(E)-2-(dimethylamino)vinyl]-8-(4-fluoroph enyl)pyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
• Synonyms: Ethyl 4-[(E)-2-(dimethylamino)vinyl]-8-(4-fluoroph enyl)pyrazolo[5,1-c][1,2,4]triazine-3-carboxylate;Ethyl 4-[(E)-2-(dimethylamino)vinyl]-8-(4-fluoroph enyl)pyrazolo[5,1-c][1,2,4]triazine-3-carboxyl;Ethyl 4-[(E)-2-(dimethylamino)vinyl]-8-(4-fluorophenyl)pyrazolo[5,1-c][1,2,4]triazine-3-carbox;4-(2-Dimethylamino-vinyl)-8-(4-fluoro-phenyl)-pyrazolo[5,1-c][1,2,4]triazine-3-carboxylic acid ethyl ester
• CAS NO: 1306753-76-3
• Molecular Formula: C18H18FN5O2
• Molecular Weight: 355.3662232
• Mol File: 1306753-76-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl 4-[(E)-2-(dimethylamino)vinyl]-8-(4-fluoroph enyl)pyrazolo[5,1-c][1,2,4]triazine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-[(E)-2-(dimethylamino)vinyl]-8-(4-fluoroph enyl)pyrazolo[5,1-c][1,2,4]triazine-3-carboxylate(1306753-76-3)
• EPA Substance Registry System: Ethyl 4-[(E)-2-(dimethylamino)vinyl]-8-(4-fluoroph enyl)pyrazolo[5,1-c][1,2,4]triazine-3-carboxylate(1306753-76-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1306753-76-3(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 5848-05-5 5-amino-4-(4-fluorophenyl)-1H-pyrazole 

Relevant articles and documents

A new class of pyrazolo[5,1-c][1,2,4]triazines as γ-aminobutyric type A (GABAA) receptor subtype ligand: synthesis and pharmacological evaluation

A comparison between compounds with pyrazolo[1,5-a]pyrimidine structure (series 4–6) and pyrazolo[5,1-c][1,2,4]triazine core (series 9) as ligands at GABAA-receptor subtype, was evaluated. Moreover, for pyrazolotriazine derivatives having binding recognition, the interaction on recombinant rat α(1–3,5) GABAA receptor subtypes, was performed. Among these latter, emerge compounds 9c, 9k, 9l, 9m and 9n as α1-selective and 9h as α2-selective ligands.