130680-58-9

Basic information

• Product Name: (R)-1-Amino-2-propanol hydrochloride
• Synonyms: (R)-1-Amino-2-propanol hydrochloride
• CAS NO: 130680-58-9
• Molecular Formula: C₃H₉NO*ClH
• Molecular Weight: 111.5706
• Mol File: 130680-58-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-1-Amino-2-propanol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-Amino-2-propanol hydrochloride(130680-58-9)
• EPA Substance Registry System: (R)-1-Amino-2-propanol hydrochloride(130680-58-9)

Safety Data

• Hazardous Substances Data: 130680-58-9(Hazardous Substances Data)

Usage

General Description

(R)-1-Amino-2-propanol hydrochloride, also known as l-aminopropan-2-ol hydrochloride, is a chemical compound with the molecular formula C3H10ClNO. It is an organic compound that contains a hydrochloride salt, which makes it a white and crystalline solid. It is commonly used as a reagent in organic synthesis and as a building block for pharmaceuticals and other fine chemicals. It can also be used as a chiral auxiliary in asymmetric synthesis and as a resolving agent in enantiomeric mixtures. (R)-1-Amino-2-propanol hydrochloride has a wide range of applications in the field of chemistry and biochemistry, making it an important and versatile chemical.

Upstream product

• 72-19-5 L-threonine 
• 130680-54-5 (2R)-N-benzyloxycarbonyl-2-(tert-butyldimethylsilyloxy)propylamine 

Downstream Products

• 162240-94-0 (R)-1-<(Phenylmethyl)amino>-2-propanol 
• 4254-14-2 (2R)-propane-1,2-diol 
• 805338-72-1 N-[(2R)-2-hydroxypropyl]-4-methylbenzene-1-sulfonamide 

Relevant articles and documents

Rapid Conventional and Microwave-Assisted Decarboxylation of L-Histidine and Other Amino Acids via Organocatalysis with R-Carvone under Superheated Conditions

This article reports a new methodology taking advantage of superheated chemistry via either microwave or conventional heating for the facile decarboxylation of alpha amino acids using the recoverable organocatalyst, R-carvone. The decarboxylation of amino acids is an important synthetic route to biologically active amines, and traditional methods of amino acid decarboxylation are time consuming (taking up to several days in the case of L-histidine), are narrow in scope, and make use of toxic catalysts. Decarboxylations of amino acids including L-histidine occur in just minutes while replacing toxic catalysts with green catalyst, spearmint oil. Yields are comparable to or exceed previous methods and purification of product ammonium chloride salts is aided by an isomerization reaction of residual catalyst to phenolic carvacrol. The method has been shown to be effective for the decarboxylations of a range of natural, synthetic, and protected amino acids.

METHOD FOR DECARBOXYLATION OF AMINO ACIDS VIA IMINE FORMATION

The present application provides methods for decarboxylation of amino acids via imine formation with a catalyst under superheated conditions in either a microwave or oil bath.