130689-85-9

Basic information

• Product Name: 2,4-Oxazolidinedione,5-phenyl-5-propyl-(9CI)
• Synonyms: 2,4-Oxazolidinedione,5-phenyl-5-propyl-(9CI)
• CAS NO: 130689-85-9
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.23652
• Product Categories: N-BOC
• Mol File: 130689-85-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-Oxazolidinedione,5-phenyl-5-propyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Oxazolidinedione,5-phenyl-5-propyl-(9CI)(130689-85-9)
• EPA Substance Registry System: 2,4-Oxazolidinedione,5-phenyl-5-propyl-(9CI)(130689-85-9)

Safety Data

• Hazardous Substances Data: 130689-85-9(Hazardous Substances Data)

Usage

Chemical Class

Oxazolidinedione

Characterized by

A phenyl ring and a propyl group attached to the oxazolidione ring structure

Usage

Organic synthesis, pharmaceutical research, building block for creating various pharmaceutical compounds, studied for potential pharmacological properties

Reagent in

Chemical reactions, particularly in the formation of heterocyclic compounds

Versatility

Potential applications in various fields, especially in the development of pharmaceuticals and organic synthesis.

Upstream product

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Relevant articles and documents

Synthesis and structure-activity relationship studies for hydantoins and analogues as voltage-gated sodium channel ligands

We previously developed a preliminary 3-D QSAR model for the binding of 14 hydantoins to the neuronal voltage-gated sodium channel; this model was successful in designing an effective non-hydantoin ligand. To further understand structural features that result in optimum binding, here we synthesized a variety of compound classes and evaluated their binding affinities to the neuronal voltage-gated sodium channel using the [3H]-batrachotoxinin A 20-α-benzoate ([3H]BTX-B) binding assay. In order to understand the importance of the hydantoin ring for good sodium channel binding, related non-hydantoins such as hydroxy amides, oxazolidinediones, hydroxy acids, and amino acids were included. Two major conclusions were drawn: (1) The hydantoin ring is not critical for compounds with long alkyl side chains, but it is important for compounds with shorter side chains. (2) Relative to Khodorov's pharmacophore, which contains two hydrophobic regions, a third hydrophobic region may enhance binding to provide nanomolar inhibitors.