130698-44-1Relevant academic research and scientific papers
The Synthesis of Certain Derivatives and Analogues of (-)- and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase
Buckler, Joshua N.,Taher, Ehab S.,Fraser, Nicolas J.,Willis, Anthony C.,Carr, Paul D.,Jackson, Colin J.,Banwell, Martin G.
, p. 7869 - 7886 (2017)
Syntheses of certain di- and mono-oxygenated derivatives (e.g., 2 and 3, respectively) and analogues (e.g., 4, a D-ring monoseco-analogue of 2) of both the (-)- and (+)-enantiomeric forms of the alkaloid galanthamine [(-)-1] are reported. All have been assessed for their capacities to inhibit acetylcholine esterase but, in contrast to the predictions from docking studies, none bind strongly to this enzyme.
