130708-02-0

Upstream product

• 79-08-3 bromoacetic acid 
• 130707-84-5 N-(2-hydroxy-5-nitrobenzyl)-1,4,7,10-tetraazacyclododecane 
• 294-90-6 1,4,7,10-tetraazacyclododecan 

Relevant academic research and scientific papers

COMPOUNDS FOR SEPARATION OF RARE EARTH ELEMENTS AND S-, P-, D- METALS, METHOD OF SEPARATION, AND USE THEREOF

The present invention relates to compounds of general formula (I) for chromatographic separation of rare earth elements and/or s-, p-, d- metals, as well as to the method of the separation of rare earth elements.

Nanosensor Compositions and Methods of use Thereof

Disclosed are compositions comprising a plastic polymer core, a shell surrounding the plastic polymer core, a ligand comprising a binding moiety, an enzyme capable of catalyzing the hydrolysis of a target compound, and a contrast agent, as well as methods

Luminescence of a binuclear europium complex bearing a 4-nitrophenolate chromophore: A different way of seeing pH dependence

A europium complex derived from NP-(DO3A)2 exhibits pH-dependent europium-centred luminescence following excitation of the nitrophenolate chromophore. Such behaviour is not observed with an analogous mononuclear complex, suggesting coordination of both lanthanide ions to the phenolate oxygen in the emissive species.

Synthesis, relaxometric and photophysical properties of a new pH-responsive MRI contrast agent: The effect of other ligating groups on dissociation of a p-nitrophenolic pendant arm

Two gadolinium(III) chelates, GdNP-DO3A (1-methlyene-(p-NitroPhenol)-1,4,7, 10-tetraazacycloDOdecane-4,7,10-triAcetate) and GdNP-DO3AM (1-methlyene(p- NitroPhenol)-1,4,7,10-tetraazacycloDOdecane-4,7,10-triacetAMide), containing a single nitrophenolic pendant arm plus either three acetate or three amide pendant arms were synthesized and characterized. The properties of the gadolinium, terbium, and dysprosium complexes of these ligands were examined as a function of pH. The extent and mechanism of the changes in water relaxivity with pH of each gadolinium complex was found to differ substantially for the two complexes. The water relaxivity of Gd(NP-DO3A) increases from 4.1 mM -1 s-1 at pH 9 to 7.0 mM-1 s-1 at pH 5 as a result of acid-catalyzed dissociation of the nitrophenol from the lanthanide. The nitrophenol group in Gd(NP-DO3AM) does not dissociate from the metal center even at pH 5; therefore, the very modest increase in relaxivity in this complex must be ascribed to an increase in prototropic exchange rate of the bound water and/or phenolic protons.

Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents

A group conjugates having a functionalized polyaminocarboxylate chelant that form complexes with rare earth-type metal ions, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.