130717-51-0 Usage
Description
FR 122047 HYDROCHLORIDE, also known as FR 122047, is a selective cyclooxygenase-1 (COX-1) inhibitor. It is a pharmaceutical compound that selectively targets COX-1, an enzyme involved in the production of prostaglandins, which are associated with inflammation and pain. FR 122047 HYDROCHLORIDE has demonstrated potent inhibition of platelet aggregation and anti-inflammatory effects, making it a promising candidate for various medical applications.
Uses
Used in Pharmaceutical Industry:
FR 122047 HYDROCHLORIDE is used as a selective COX-1 inhibitor for its potent anti-inflammatory and anti-platelet aggregation properties. It is particularly effective in inhibiting arachidonic acid, collagen, and ADP-induced platelet aggregation, with an IC50 of 180-200 nM, which is nearly 100 times more potent than aspirin. This selective inhibition makes it a potential candidate for the development of new anti-inflammatory and anti-thrombotic drugs.
Additionally, FR 122047 HYDROCHLORIDE has been shown to have an anti-inflammatory effect in some models of inflammation, such as collagen-induced arthritis in rats. This suggests a potential role for COX-1 in these models and the possibility of using FR 122047 HYDROCHLORIDE as a therapeutic agent for treating inflammatory conditions.
Biological Activity
Selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.028 and 65 μ M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 130717-51-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,7,1 and 7 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 130717-51:
(8*1)+(7*3)+(6*0)+(5*7)+(4*1)+(3*7)+(2*5)+(1*1)=100
100 % 10 = 0
So 130717-51-0 is a valid CAS Registry Number.
InChI:InChI=1/C23H25N3O3S.ClH/c1-25-12-14-26(15-13-25)23(27)22-24-20(16-4-8-18(28-2)9-5-16)21(30-22)17-6-10-19(29-3)11-7-17;/h4-11H,12-15H2,1-3H3;1H
