130721-78-7

Basic information

• Product Name: (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER;2-BOC-AMINO-4-CHLOROPYRIDINE;tert-Butyl (4-chloropyridin-2-yl)carbamate;tert-butyl N-(4-chloropyridin-2-yl)carbamate
• CAS NO: 130721-78-7
• Molecular Formula: C₁₀H₁₃ClN₂O₂
• Molecular Weight: 228.68
• Product Categories: pharmacetical
• Mol File: 130721-78-7.mol
• Article Data: 23

Chemical Properties

• Melting Point: (dec)
• Boiling Point: 274℃
• Flash Point: 120℃
• Appearance: White to off-white powder
• Density: 1.245
• Vapor Pressure: 0.00545mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 11.89±0.70(Predicted)
• CAS DataBase Reference: (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER(130721-78-7)
• EPA Substance Registry System: (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER(130721-78-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 130721-78-7(Hazardous Substances Data)

Usage

General Description

(4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester is a chemical compound with the formula C9H11ClN2O2. It is a derivative of carbamic acid and contains a tert-butyl ester group and a chloropyridine group. (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER is commonly used in the synthesis of pharmaceuticals and agrochemicals, and it also has biological activity. Its properties and structure make it potentially useful in the development of new drugs and pesticides. Additionally, it is important to handle this compound with care as it may have potential health hazards if not used properly.

InChI:InChI=1/C10H13ClN2O2/c1-10(2,3)15-9(14)13-8-6-7(11)4-5-12-8/h4-6H,1-3H3,(H,12,13,14)

Upstream product

• 1036648-06-2 4-chloropyridine-2-carboxylic acid hydrochloride 
• 75-65-0 tert-butyl alcohol 
• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 98-98-6 2-Picolinic acid 
• 10177-29-4 4-chloronicotinic acid 
• 5470-22-4 4-chloropicolinic acid 
• 19798-80-2 2-Amino-4-chloropyridine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1528549-08-7 C₃₀H₂₆F₂N₄O₅ 
• 1528546-94-2 N-(4-(2,3-dihydro-1H-pyrrolo[2,3-b] pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1454913-60-0 tert-butyl 4-(4-chloro-2-fluorophenyl)-3-formylpyridin-2-ylcarbamate 
• 1454913-61-1 2-amino-4-(4-chloro-2-fluorophenyl)nicotinaldehyde 
• 1454913-62-2 (2-amino-4-(4-chloro-2-fluorophenyl)pyridin-3-yl)methanol 
• 1454913-67-7 1-(2-amino-4-(4-chloro-2-fluorophenyl)pyridin-3-yl)ethanol 
• 605661-83-4 2-amino-4-chloronicotinic acid 
• 782439-26-3 4-chloro-N-methylpyridin-2-amine 

Relevant articles and documents

EIF4E INHIBITORS AND USES THEREOF

The present invention provides compounds inhibiting elF4E activity and compositions and methods of using thereof.

IMIDAZOPIPERAZINE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS

The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.

Synthesis and evaluation of the anticoccidial activity of trifluoropyrido[1,2-a]pyrimidin-2-one derivatives

Screening of our chemical library to discover new molecules exhibiting in vitro activity against the invasion of host cells by Eimeria tenella revealed a lead compound with an IC50 of 15 μM. Structure-activity relationship studies were conducted with 34 newly synthesized compounds to identify more active molecules and enhance in vitro activity against the parasite. Four compounds were more effective in inhibiting MDBK cell invasion in vitro than the lead compound.