130722-44-0

Basic information

• Product Name: 1-(benzyloxy)-3-broMo-5-fluorobenzene
• Synonyms: 1-(benzyloxy)-3-broMo-5-fluorobenzene;3-benzyloxy-1-bromo-5-fluorobenzene;1-(Benzyloxy)-5-bromo-3-fluorobenzene;-3-bromo-5-fluorobenzene
• CAS NO: 130722-44-0
• Molecular Formula: C₁₃H₁₀BrFO
• Molecular Weight: 281.1203032
• Mol File: 130722-44-0.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(benzyloxy)-3-broMo-5-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzyloxy)-3-broMo-5-fluorobenzene(130722-44-0)
• EPA Substance Registry System: 1-(benzyloxy)-3-broMo-5-fluorobenzene(130722-44-0)

Safety Data

• Hazardous Substances Data: 130722-44-0(Hazardous Substances Data)

Usage

General Description

1-(benzyloxy)-3-bromo-5-fluorobenzene is a chemical compound with the molecular formula C13H10BrFO. It is a derivative of benzene with a benzyl ether group (benzyloxy), a bromine atom, and a fluorine atom attached to the benzene ring. 1-(benzyloxy)-3-broMo-5-fluorobenzene is commonly used in organic synthesis and medicinal chemistry as a building block for creating more complex molecules. It has also been studied for its potential biological and pharmacological properties. The presence of the bromine and fluorine atoms makes this compound interesting for its potential use in pharmaceuticals or as a reagent in chemical reactions.

Upstream product

• 461-96-1 3,5-difluorobromobenzene 
• 100-51-6 benzyl alcohol 
• 128-08-5 N-Bromosuccinimide 
• 130723-09-0 4-(5-fluoro-3-hydroxyphenyl)-4-methoxy-3,4,5,6-tetrahydro-2H-pyran 
• 845866-85-5 1-bromo-3-fluoro-5-iodobenzene 
• 433939-27-6 3-bromo-5-fluorophenol 
• 100-39-0 benzyl bromide 
• 29578-39-0 1-bromo-3-fluoro-5-methoxybenzene 

Downstream Products

• 861446-28-8 5-benzyloxy-3,4'-difluorostilbene 
• 915378-82-4 4'-acetoxy-3-fluoro-5-hydroxystilbene 
• 130723-10-3 4-(3-Benzyloxy-5-fluorophenyl)-4-hydroxytetrahydropyran 
• 103-50-4 dibenzyl ether 
• 1345021-15-9 3-(2-(3-fluoro-5-(4-(4-methoxytetrahydropyranyl))phenoxy)ethyl)-6-nitro-1,3,2-benzodithiazolium ylide 1,1-dioxide 
• 1345021-21-7 4-(3-(2-bromoethoxy)-5-fluorophenyl)-4-methoxy-3,4,5,6-tetrahydro-2H-pyran 
• 1345021-22-8 4-(3-fluoro-5-(2-mercaptoethoxy)phenyl)-4-methoxy-3,4,5,6-tetrahydro-2H-pyran 
• 156353-11-6 3-methyl-3-[(3-benzyloxy-5-fluorophen-1-yl)hydroxymethyl]oxetane 
• 133739-66-9 6-<<3-fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl)phenoxy>methyl>-1-<(pivaloyloxy)methyl>quinol-2-one 
• 139486-95-6 5-bromo-1,3-dimethyl-6-<<3-fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl)phenoxy>methyl>benzimidazolin-2-one 
• 139486-96-7 4-[5-fluoro-3-(1,3-dimethyl-2-oxo-2,3-dihydrobenzimidazol-5-ylmethoxy)phenyl]-4-methoxytetrahydropyran 
• 141376-48-9 3-Bromo-6-[3-fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-1-methyl-1H-quinolin-4-one 
• 141396-42-1 4-Bromo-6-[3-fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-2-methyl-2H-isoquinolin-1-one 
• 141376-46-7 6-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-1-methyl-1H-quinoxalin-2-one 

Relevant articles and documents

Compounds and methods of use

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X1, X2, X3, X4, Y, A, L1, L2, R1, R2, R5, m and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS

The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

PROTEIN KINASE INHIBITORS

The present invention relates to a novel family of inhibitors o f protein kinase of formula 1 and process for their production and pharmaceutical compositions thereof. In particular, the present invention relates to inhibitors of the members of the Tec, Src and Btk protein kinase families