1307233-94-8

Basic information

• Product Name: ethyl 3-(2-(chloroMethyl)-1-Methyl-N-(pyridin-2-yl)-1H-benzo[d]iMidazole-5-carboxaMido)propanoate
• Synonyms: ethyl 3-(2-(chloroMethyl)-1-Methyl-N-(pyridin-2-yl)-1H-benzo[d]iMidazole-5-carboxaMido)propanoate;N-[[2-(Chloromethyl)-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester;Ethyl 3-(2-(chloromethyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propano
• CAS NO: 1307233-94-8
• Molecular Formula: C₂₀H₂₁ClN₄O₃
• Molecular Weight: 402.87462
• Mol File: 1307233-94-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 609.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.29
• PKA: 3.71±0.10(Predicted)
• CAS DataBase Reference: ethyl 3-(2-(chloroMethyl)-1-Methyl-N-(pyridin-2-yl)-1H-benzo[d]iMidazole-5-carboxaMido)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(2-(chloroMethyl)-1-Methyl-N-(pyridin-2-yl)-1H-benzo[d]iMidazole-5-carboxaMido)propanoate(1307233-94-8)
• EPA Substance Registry System: ethyl 3-(2-(chloroMethyl)-1-Methyl-N-(pyridin-2-yl)-1H-benzo[d]iMidazole-5-carboxaMido)propanoate(1307233-94-8)

Safety Data

• Hazardous Substances Data: 1307233-94-8(Hazardous Substances Data)

Usage

Uses

Ethyl 3-(2-(Chloromethyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate is an intermediate used to synthesize dabigatran etexilate.

Upstream product

• 51076-95-0 2-chloro-1,1,1-triethoxyethane 
• 212322-56-0 ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate 

Downstream Products

• 211915-06-9 dabigatran etexilate 
• 872728-81-9 N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl] amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-β-alanine ethyl ester methanesulfonate 
• 429658-95-7 3-({2-[(4-carbamimidoylphenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)propionic acid ethyl ester 
• 1408238-40-3 ethyl 3-[[[2-[[[4-[[[(hexyloxy)carbonyl]amino]carbonyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propanoate 

Relevant articles and documents

Preparation method of Pradaxa intermediate

The invention belongs to the technical field of medicine preparation, and particularly relates to a preparation method of a Pradaxa intermediate. An adopted compound 6 has the characteristics of stable properties, no irritating odor, low price and the like. The defects that acid anhydride or acyl chloride compounds having the disadvantages of irritating odor, hygroscopicity and a high requirementfor an anhydrous reaction system are adopted in an existing synthesis route of the Pradaxa intermediate can be overcome. The reaction process has easier operation and control, high selectivity and stable yield.