130727-46-7Relevant articles and documents
Guided assemblies of ferritin nanocages: Highly ordered arrays of monodisperse nanoscopic elements
Hu, Yunxia,Chen, Dian,Park, Soojin,Emrick, Todd,Russell, Thomas P.
, p. 2583 - 2587 (2010)
(Figure Presented) High-density arrays of highly ordered ferritin nanocages are fabricated through the guided assembly of thiol-modified ferritin on prepatterned gold nanodots, which are prepared by block copolymer micelle lithography. One and only one fe
Simultaneous Exfoliation and Functionalization of 2H-MoS2 by Thiolated Surfactants: Applications in Enhanced Antibacterial Activity
Karunakaran, Subbaraj,Pandit, Subhendu,Basu, Bikramjit,De, Mrinmoy
, p. 12634 - 12644 (2018)
Two-dimensional transition metal dichalcogenides (TMDs), such as MoS2, generally exist in two different polymorphic structures, metallic (1T phase) and semiconducting (2H phase). In context of their wide spectrum of applications ranging from electronic to biomedicine, the aspects of ligand conjugation and solution processability are highly significant. In addition, the assessment of their antibacterial property and biocompatibility is equally important to explore their biomedical applications. Here we report a new method for the exfoliation and direct functionalization of 2H-MoS2 using surfactant molecules with thiol functionality. We found that the exfoliated MoS2 using thiolated ligands are functionalized with desired functionality and the processing scheme can be extended to other TMDs. Functionalized 2H-MoS2 exhibits highly enhanced antibacterial efficiency compared to similarly functionalized metallic 1T-MoS2 against pathogenic bacteria. The newly synthesized functionalized 2H-MoS2 exhibits better hemocompatibility, which makes it suitable for in vivo applications. This convenient functionalization method opens the door for many other applications of functionalized semiconducting 2H-MoS2 and other TMDs.
On-demand electrochemical activation of the click reaction on self-assembled monolayers on gold presenting masked acetylene groups
Choi, Inseong,Kim, Young-Kwan,Min, Dal-Hee,Lee, Sangwook,Yeo, Woon-Seok
, p. 16718 - 16721 (2011)
We report on a new surface modification method for grafting a "dynamic" property for on-demand activation of the click reaction. Our approach utilizes the acetylene group masked with dicobalt hexacarbonyl, Co2(CO)6, which is not reactive toward the click reaction. Electrochemical treatment reveals the acetylene group on the selected region, which is then used as a chemical handle for surface functionalization via the click reaction with an azide-containing molecule. Electrochemical and chemical conversions on the surface were verified by cyclic voltammetry, X-ray photoelectron spectroscopy, and fluorescence spectroscopy. We have demonstrated immobilization of an azide-modified RGD peptide and promotion of cell adhesion/migration to the region of electrochemical induction.
Compositions and Methods for Treating Disease Using Salmonella T3SS Effector Protein (SipA)
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Paragraph 0141; 0165, (2017/04/14)
The invention provides compositions and methods for reducing one or more symptoms of disease by administering compositions comprising SipA. The invention's compositions and methods are particularly advantageous in reducing symptoms of diseases that are associated with overexpression of P-gp and/or p53. The invention's compositions and methods are useful in reducing cancer symptom and/or cancer multidrug resistance (MDR). The invention provides a method for reducing one or more symptoms of cancer in a mammalian subject in need thereof, comprising administering to said subject a composition comprising purified SipA. In one embodiment, said SipA is operably conjugated to a nanoparticle. In another embodiment, said cancer comprises cancer cells resistant to at least one cytotoxin.
Microorganism detection and analysis using carbohydrate and lectin recognition
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Page/Page column 11, (2016/09/26)
Methods of binding and detecting a microorganism on a solid substrate. The microorganism is bound on a solid substrate covalently bound to a capture agent having a saccharide moiety. A lectin capable of binding to the microorganism and the saccharide moiety of the capture agent is added to the sample to bind the microorganism on the solid substrate. Further provided are biosensor devices, such as a quartz crystal microbalance (QCM) device or a surface plasmon resonance (SPR) device, that incorporate the solid substrate for the detection of microorganisms.
Ligand conjugation of chemically exfoliated MoS2
Chou, Stanley S.,De, Mrinmoy,Kim, Jaemyung,Byun, Segi,Dykstra, Conner,Yu, Jin,Huang, Jiaxing,Dravid, Vinayak P.
supporting information, p. 4584 - 4587 (2013/05/22)
MoS2 is a two-dimensional material that is gaining prominence due to its unique electronic and chemical properties. Here, we demonstrate ligand conjugation of chemically exfoliated MoS2 using thiol chemistry. With this method, we modulate the ζ-potential and colloidal stability of MoS2 sheets through ligand designs, thus enabling its usage as a selective artificial protein receptor for β-galactosidase. The facile thiol functionalization route opens the door for surface modifications of solution processable MoS2 sheets.
6-Aminopenicillanic acid (6-APA) derivatives equipped with anchoring arms
Favre, Anna?ck,Grugier, Jér?me,Brans, Alain,Joris, Bernard,Marchand-Brynaert, Jacqueline
supporting information, p. 10818 - 10826 (2013/01/15)
6-APA derivatives were considered as selective labels for the construction of bifunctional linkers dedicated to the oriented immobilization of proteins on materials. Sulbactam-like compounds (i.e., 6-β-sulfonamido-penam sulfones) and penicillin G - like compounds (i.e., para-substituted 6-β- phenylacetamido-penams) were prepared and tested as irreversible inhibitors of representative β-lactamases and D,D-peptidases, respectively. The activity of the modified antibiotics was preserved despite their substitution with various anchoring arms. The (2-nitro-4,5-dimethoxy)-benzyl esters revealed of particular interest due to their capacity to acylate BlaR-CTD without deprotection.
Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors
Hierrezuelo, Jesús,Manuel López-Romero,Rico, Rodrigo,Brea, José,Isabel Loza,Cai, Chengzhi,Algarra, Manuel
experimental part, p. 2081 - 2088 (2010/06/14)
The synthesis of oligo(ethylene glycol)-alkene substituted theophyllines in positions 7 and/or 8 is described. The binding activity at adenosine receptors of selected derivatives was studied. Compound 2 showed high affinity for human A2B receptor (Ki = 4.16 nM) with a selectivity KiA2A/KiA2B of 24.1, and a solubility in water of 1 mM. The alkenyl substituent in some of the theophylline derivatives allows for covalent attachment of them onto hydrogen-terminated silicon substrate surfaces via hydrosilylation. Alternatively, an azido group was incorporated to an oligo(ethylene glycol)theophylline derivative as an anchor for tethering the molecules on ethynyl presenting surfaces via click reaction.
