130733-86-7

Upstream product

• 81683-96-7 6-(hydroxymethyl)tetrahydro-2H-pyran-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 130733-87-8 6-(tert-butyldiphenylsilyloxymethyl)-1,4-dioxaspiro<4,4>nonane 
• 130733-88-9 2-(((tert-butyldiphenylsilyl)oxy)methyl)cyclopentan-1-one 

Downstream Products

• 1078697-24-1 6-(tert-butyldiphenylsilyloxy)-5-hydroxy-N-methoxy-N-methylhexanamide 
• 553670-71-6 6-benzenesulfanyl-2-(tert-butyldiphenylsilyloxymethyl)-3,4-dihydro-2H-pyran 

Relevant academic research and scientific papers

Efficient oxidative cyclization of 1,6-dienes: A highly diastereoselective entry to substituted tetrahydropyrans

(Chemical Equation Presented) Widely applicable: Substituted tetrahydropyran products can be obtained in good to high yields and excellent diastereoselectivity by oxidative cyclization of 1,6-dienes (see scheme, PG = protecting group). In situ generated r

Remarkable rate acceleration of the solvent-free Baeyer-Villiger reaction on the surface of NaHCO3 crystals for sterically congested cyclic and acyclic ketones

Baeyer-Villiger reactions of sterically crowded cyclic and acyclic ketones are remarkably accelerated by carrying out the reactions under solvent-free conditions in the presence of powdered NaHCO3. The corresponding lactones and esters have been obtained in excellent yields.

An Efficient Baeyer-Villiger Approach to 6-(Hydroxymethyl)tetrahydro-2H-pyran-2-one Derivatives

An efficient (64percent overall yield) five step preparation of 6-(tert-butyldiphenylsiloxymethyl)tetrahydro-2H-pyran-2-one from ethyl 2-oxocyclopentane carboxylate is reported.

A synthesis of α-lithiated enol ethers from α-arenesulfinyl enol ethers: Ni(0)- and Pd(0)-catalysed coupling of enol triflates and phosphates derived from lactones with sodium arenethiolates gives α-arenesulfanyl enol ethers

A three-step synthesis of stable and storable α-benzene-sulfinyl enol ethers from lactones entails (a) conversion of a lactone to an enol triflate or phosphate; (b) Ni(0) and Pd(0) cross-coupling of the enol triflate or phosphate with a sodium arenethiolate to give an α-arenethio enol ether; and (c) oxidation of an arenethio group to a sulfoxide. The α-benzenesulfinyl enol ethers undergo sulfoxide-lithium exchange on reaction with n-BuLi to give α-lithiated enol ethers thus making the α-benzenesulfinyl group a surrogate for the trialkylstannyl group which has hitherto served as the most common precursor to α-lithiated enol ethers.