130739-76-3

Upstream product

• 130739-67-2 5-(4-Fluoro-phenyl)-5-oxo-3-phenyl-pentanoic acid 
• 136678-67-6 2-(3-(4-fluorophenyl)-3-oxo-1-phenylpropyl)malonate 
• 399-10-0 4'-fluorochalcone 
• 130739-61-6 [3-(4-Fluorophenyl)-3-oxo-1-phenylpropyl]propanedioic acid, diethyl ester 

Downstream Products

• 130739-81-0 2-(4-Fluorophenyl)-6-oxo-4-phenyl-1-cyclohexene-1-carboxylic acid, ethyl ester 

Relevant academic research and scientific papers

Process for preparing highly substituted phenyls

A process is described in which a lactone STR1 is reacted with an alkylester X1 --CH2 and an oxidizing or dehydrogenating agent to form the phenol ester STR2

A new and versatile route for the synthesis of highly substituted benzenoids

A new route for the synthesis of highly substituted benzenoids has been developed. Key steps include the conversion of unsaturated lactone 7 to carboxy substituted cyclohexenone 8 followed aromatization to give phenol 9. The phenolic functionality provides a handle for further modification to give substituted benzenoids of type 2.