13074-21-0

Basic information

• Product Name: (2S)-2-acetamido-5-oxo-pentanoic acid
• Synonyms: (2S)-2-acetamido-5-oxo-pentanoic acid;N-Acetyl-L-glutamate 5-semialdehyde
• CAS NO: 13074-21-0
• Molecular Formula: C7H11NO4
• Molecular Weight: 0
• Mol File: 13074-21-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 466°Cat760mmHg
• Flash Point: 235.6°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 5.67E-10mmHg at 25°C
• Refractive Index: 1.471
• CAS DataBase Reference: (2S)-2-acetamido-5-oxo-pentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-acetamido-5-oxo-pentanoic acid(13074-21-0)
• EPA Substance Registry System: (2S)-2-acetamido-5-oxo-pentanoic acid(13074-21-0)

Safety Data

• Hazardous Substances Data: 13074-21-0(Hazardous Substances Data)

Usage

Description

(2S)-2-acetamido-5-oxo-pentanoic acid, also known as N-acetyl-D-glutamic acid, is a chemical compound with the molecular formula C7H11NO5. It is a derivative of glutamic acid and is commonly found in the human body as a byproduct of metabolic processes. (2S)-2-acetamido-5-oxo-pentanoic acid plays a crucial role in maintaining homeostasis and overall health.

Uses

Used in Pharmaceutical Industry:
(2S)-2-acetamido-5-oxo-pentanoic acid is used as a precursor in the synthesis of antibiotics and other pharmaceuticals. Its presence in the human body is essential for various metabolic processes, making it a valuable component in the development of new drugs.
Used in Neurodegenerative Disease Treatment:
(2S)-2-acetamido-5-oxo-pentanoic acid is studied for its potential role in the treatment of neurodegenerative diseases. Its ability to modulate the immune system and impact metabolic processes suggests that it may have therapeutic benefits for patients suffering from such conditions.
Used in Immune System Modulation:
(2S)-2-acetamido-5-oxo-pentanoic acid has been studied for its ability to modulate the immune system. This property makes it a promising candidate for the development of treatments targeting immune-related disorders and conditions.

InChI:InChI=1/C7H11NO4/c1-5(10)8-6(7(11)12)3-2-4-9/h4,6H,2-3H2,1H3,(H,8,10)(H,11,12)/t6-/m0/s1

Upstream product

• 6205-08-9 N^α-acetyl-S-ornithine 

Relevant articles and documents

Antioxidant and pro-oxidant actions of resveratrol on human serum albumin in the presence of toxic diabetes metabolites: Glyoxal and methyl-glyoxal

Methylglyoxal (MGO) and glyoxal (GO) are attracting considerable attention because of their role in the onset of diabetes symptoms. Therefore, to comprehend the molecular fundamentals of their pathological actions is of the utmost importance. In this study, the molecular interactions between resveratrol (RES) and human serum albumin (HSA) and the ability of the stilbene to counteract the oxidative damage caused by pathological concentrations of MGO and GO to the human plasma protein, was assessed. The oxidation of Cys34 in HSA as well as the formation of specific protein semialdehydes AAS (α-aminoadipic), GGS (γ-glutamic) and the accumulation of Advanced Glycation End-products (AGEs) was investigated. Resveratrol was found to neutralize both α-dicarbonyls by forming adducts detected by HESI-Orbitrap-MS. This antioxidant action was manifested in a significant reduction of AGEs. However, RES-α-dicarbonyl conjugates oxidized Cys34 and lysine, arginine and/or proline by a nucleophilic attack on SH and ε-NH groups in HSA. The formation of specific semialdehydes in HSA after incubation with GO and MGO at pathological concentrations was reported for the first time in this study, and may be used as early and specific biomarkers of the oxidative stress undergone by diabetic patients. The pro-oxidative role of the RES-α-dicarbonyl conjugates should be further investigated to clarify whether this action leads to positive or harmful clinical consequences. The biological relevance of human protein carbonylation as a redox signaling mechanism and/or as a reflection of oxidative damage and disease should also be studied in future works.