130741-19-4Relevant academic research and scientific papers
Synthesis and antiproliferative activities of ottelione a analogues
Chang, Tsai-Yuan,Tu, Yun-Peng,Wei, Win-Yin,Chen, Hsiang Yu,Chen, Chih-Shang,Lee, Ying-Shuan E.,Huang, Jiann-Jyh,Sha, Chin-Kang
, p. 1075 - 1080 (2012)
Through the syntheses of its C-1 desvinyl, C-7 methylene, C-7 exocyclic ethylidene, and various C-3 phenylmethyl analogues, the structure-Activity relationship of antimitotic ottelione A (4) against tubulin and various cancer cells was established. The re
α-Carbonyl Radicals for Total Synthesis of Natural Products
Sha, Chin-Kang,Jean, Tsong-Shin,Yau, Nei-Tung,Huang, Shih-Jung,Chiou, Ruey-Torn,et al.
, p. 637 - 640 (2007/10/02)
Intramolecular cyclization of α-carbonyl radicals to the trimethylsilylacetylenic side chain gives bicyclic vinylsilane ketones and enones.Application of the cyclization to total synthesis of (+/-)-modhephene is described.
INTRAMOLECULAR RADICAL CYCLIZATION OF SILYLACETYLENIC OR OLEFINIC α-IODO KETONES: APPLICATION TO THE TOTAL SYNTHESIS OF (+/-)-MODHEPHENE
Sha, Chin-Kang,Jean, Tsong-Shin,Wang, Deh-Chi
, p. 3745 - 3748 (2007/10/02)
Silylacetylenic or olefinic α-iodo ketones were treated with tributyltin hydride and AIBN to give bicyclic ketones by an intramolecular α-carbonyl radical cyclization reaction.As an application of this radical cyclization reaction, the total synthesis of
