130741-22-9Relevant academic research and scientific papers
INTRAMOLECULAR RADICAL CYCLIZATION OF SILYLACETYLENIC OR OLEFINIC α-IODO KETONES: APPLICATION TO THE TOTAL SYNTHESIS OF (+/-)-MODHEPHENE
Sha, Chin-Kang,Jean, Tsong-Shin,Wang, Deh-Chi
, p. 3745 - 3748 (1990)
Silylacetylenic or olefinic α-iodo ketones were treated with tributyltin hydride and AIBN to give bicyclic ketones by an intramolecular α-carbonyl radical cyclization reaction.As an application of this radical cyclization reaction, the total synthesis of
α-Carbonyl Radicals for Total Synthesis of Natural Products
Sha, Chin-Kang,Jean, Tsong-Shin,Yau, Nei-Tung,Huang, Shih-Jung,Chiou, Ruey-Torn,et al.
, p. 637 - 640 (2007/10/02)
Intramolecular cyclization of α-carbonyl radicals to the trimethylsilylacetylenic side chain gives bicyclic vinylsilane ketones and enones.Application of the cyclization to total synthesis of (+/-)-modhephene is described.
