1307725-41-2Relevant academic research and scientific papers
Nickel-Catalyzed [2+2+2] Cycloaddition of Alkyne-Nitriles with Alkynes Assisted by Lewis Acids: Efficient Synthesis of Fused Pyridines
You, Xu,Xie, Xin,Wang, Gaonan,Xiong, Meijun,Sun, Renhong,Chen, Haoyi,Liu, Yuanhong
, p. 16765 - 16769 (2016)
A Ni/BPh3catalyzed [2+2+2] cycloaddition of alkyne-nitriles with alkynes has been developed, which provides an efficient route to fused pyridines under mild reaction conditions. Mechanistic studies indicate that an azanickelacycle via heterocoupling of an alkyne with a nitrile moiety is possibly formed as a key reaction intermediate. The Lewis acid catalyst is crucial to the successful transformation, which is suggested to promote the oxidative cyclization process.
Iron-catalyzed cycloaddition of alkynenitriles and alkynes
Dsouza, Brendan R.,Lane, Timothy K.,Louie, Janis
supporting information; experimental part, p. 2936 - 2939 (2011/07/09)
The combination of Fe(OAc)2 and an electron-donating, sterically hindered pyridyl bisimine ligand catalyzes the cycloaddition of alkynenitriles and alkynes. A variety of substituted pyridines were obtained in good yields.
