1307799-79-6Relevant articles and documents
Novel pyrrolidine melanin-concentrating hormone receptor 1 antagonists with reduced hERG inhibition
Fox, Brian M.,Natero, Reina,Richard, Kevin,Connors, Richard,Roveto, Philip M.,Beckmann, Holger,Haller, Katrin,Golde, Justin,Xiao, Shou-Hua,Kayser, Frank
, p. 2460 - 2467 (2011)
We discovered novel pyrrolidine MCHR1 antagonist 1 possessing moderate potency. Profiling of pyrrolidine 1 demonstrated that it was an inhibitor of the hERG channel. Investigation of the structure-activity relationship of this class of pyrrolidines allowe