1307826-86-3

Upstream product

• 1229158-78-4 ethyl (1R,2R,3R,4S)-3-azido-4-(tert-butoxycarbonylamino)-2-hydroxycyclopentanecarboxylate 
• 536-74-3 phenylacetylene 

Downstream Products

• 1307826-88-5 tert-butyl (1S,2R,3R,4S)-3-hydroxy-4-(hydroxymethyl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)cyclopentylcarbamate 

Relevant academic research and scientific papers

Synthesis of regio-and stereoisomers of highly functionalized 1,2,3-triazole-substituted cyclopentanes

Highly functionalized regio-and stereoisomers of 1,2,3-triazole-substituted cyclopentanes were prepared in six steps from either bicyclic β-lactam 7 or γ-lactam 23 by 1,3-dipolar cycloaddition of the azido cyclopentanol intermediates with acetylenes. The reactions of azido aminocyclopentanols with non-symmetric acetylenes resulted regioselectively in the corresponding 1,4-disubstitued triazole derivatives under both thermal and Cu(I)-catalysed conditions. These compounds can be regarded as highly functionalized 1,2,3-triazole-modified carbocyclic nucleoside analogues.