1307877-55-9Relevant academic research and scientific papers
Facile routes for the preparation of 3,4-disubstituted 1,3-oxazolidines and 1,2,5-trisubstituted imidazolidin-4-ones
Catalano, Alessia,Carocci, Alessia,Lentini, Giovanni,Di Mola, Antonia,Bruno, Claudio,Franchini, Carlo
experimental part, p. 261 - 266 (2011/06/10)
Facile, alternative synthetic routes to (RS)-, (R)-, and (S)-3-benzyl-N-(2,6-dimethylphenyl)-1,3-oxazolidine-4-carboxamides (6), a chiral oxazolidine derivative of tocainide, are reported. The synthetic routes described herein also afforded (RS)-, (R)-, and (S)-11, which present the imidazolidin-4-one core and belong to a class of compounds interesting for their biological activities. All the final compounds and intermediates were fully characterized. Enantiomeric excesses of homochiral 6 and 11 were determined by capillary electrophoresis analysis using 2-hydroxypropyl-β-cyclodextrin or highly sulfated γ-cyclodextrin as chiral selectors.
