1307886-16-3Relevant academic research and scientific papers
Gold-Catalyzed Dehydrogenative Cycloisomerization of 1,4-Enyne Esters to 3,5-Disubstituted Phenol Derivatives
Chen, Cuili,Chen, Xianxiao,Zhang, Xiaoxiang,Wang, Shifa,Rao, Weidong,Chan, Philip Wai Hong
supporting information, p. 4359 - 4368 (2017/12/26)
A method to prepare synthetically important 3,5-disubstituted phenol derivatives that relies on the sequential gold(I)-catalyzed dehydrogenative cycloisomerization of 1,4-enyne esters in the presence of 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) or N-fluorobenzenesulfonimide (NFSI) is described. The synthetic versatility of the methodology was exemplified by a gram-scale reaction of one example, the ease to realize subsequent functional transformations of an adduct, and the application of the method to the synthesis of the bioactive molecule LUF5771. (Figure presented.).
Electrophilic carbocyclization of hydroxylated enynes
Yang, Fang,Ji, Ke-Gong,Zhu, Hai-Tao,Shaukat, Ali,Liu, Xue-Yuan,Liang, Yong-Min
, p. 4986 - 4990 (2011/05/30)
Mild, efficient, and clean! Six-membered cyclic products including diiodocyclohexadiene and 2,3-diiodobenzene have been prepared in a iodonium-induced internal carbocyclization of hydroxylated enynes (see scheme). This reaction proceeds smoothly under mild reaction conditions, and all the halogen atoms (I and Br) generated from the electrophiles are used effectively.
