1307910-91-3

Upstream product

• 100-46-9 benzylamine 
• 54436-58-7 N-benzylpent-4-en-1-amine 
• 108-24-7 acetic anhydride 
• 1119-51-3 bromopentene 

Downstream Products

• 54436-58-7 N-benzylpent-4-en-1-amine 
• 1610026-58-8 N-benzyl-N-(pent-4-en-1-yl)ethanethioamide 
• 1307910-95-7 2-benzyl-1-methyl-2-azabicyclo[4.1.0]heptane 

Relevant academic research and scientific papers

Ti-mediated intramolecular cyclopropanation of N-alkenyl thioamides: Scope and mechanistic study

Although thioamides generally undergo a reductive alkylation process when they are treated with a Grignard reagent in the presence of Ti(OiPr) 4, substrates fitted with a but-3-enyl substitution at the nitrogen atom are shown to be converted into bicyclic aminocyclopropanes. These reactions are compared with the similar cyclisations of the corresponding carboxylic amide substrates. A mechanistic study is provided. Coincidently, new reagent systems are identified for the mediation of the same transformation.