130792-56-2Relevant articles and documents
Chiral induction in cyclopentyl-derived 1,3-meso-diesters: enantioselective hydrolyses with electric eel acetylcholinesterase
Deardorff, Donald R.,Amador, Roberto B.,Morton, James W.,Kim, Henry Y.,Taniguchi, Cullen M.,Balbuena, Arnel A.,Warren, Sam A.,Fanous, Vadim,Choe, S. W. Tina
, p. 2139 - 2152 (2007/10/03)
Eight 1,3-meso-diesters derived from a common cyclopentyl backbone were exposed to the hydrolase enzyme acetylcholinesterase from Electrophorus electricus. All eight compounds were hydrolyzed by the enzyme. The overall enantioselectivities were quite high, and the resulting e.e.s were generally >90%. The absolute configurations of the product monoesters were determined through stereochemical correlation. These data revealed that the preferred site for enzymatic hydrolysis in seven of the substrates was the pro-S ester function, with pro-R cleavage detected in the eighth.
