130798-47-9Relevant articles and documents
Ligand-accelerated enantioselective propargylation of aldehydes via allenylzinc reagents
Trost, Barry M.,Ngai, Ming-Yu,Dong, Guangbin
supporting information; experimental part, p. 1900 - 1903 (2011/06/21)
An enantioselective propargylation of aldehydes using an allenylzinc reagent generated in situ via a zinc-iodine exchange reaction is described. The enantioselectivity is controlled by addition of a catalytic amount of readily accessible and highly tunable amino alcohol ligand L13. A wide range of aldehydes can be propargylated to afford valuable and versatile homopropargyl alcohols in good to excellent yields with high levels of enantiopurity.