13080-78-9

Upstream product

• 131-57-7 Benzophenone-3 
• 106-95-6 allyl bromide 
• 1159707-78-4 (2-allyloxy-4-methoxyphenyl)phenylmethanol 

Downstream Products

• 1159707-89-7 2-allyloxy-4-methoxy-1-(1-phenylvinyl)benzene 
• 134617-18-8 (Z)-9-Methoxy-6-phenyl-4H,6H-benzo[b][1,5]oxathiocine 
• 121150-36-5 (2-Allyloxy-4-methoxy-phenyl)-phenyl-methanethione 

Relevant academic research and scientific papers

Thermally-Induced Intramolecular [4+2] Cycloaddition of Allylamino- or Allyloxy-Tethered Alkylidenecyclopropanes

A thermally-induced intramolecular [4+2] cycloaddition reaction of allylamino- or allyloxy-tethered alkylidenecyclopropanes has been reported in this paper, giving a new protocol for the rapid construction of polycyclic skeleton molecules in moderate to e

Synthesis of Allyl- and Prenylcoumarins via Microwave-Promoted Tandem Claisen Rearrangement/Wittig Olefination

Allyl, dimethylallyl, crotyl, and prenyl ethers of various aromatic ortho-hydroxy carbonyl compounds undergo a tandem sequence of Claisen rearrangement, carbonyl olefination, and cyclization upon microwave irradiation in the presence of a stabilized ylide. The products are multiply substituted 6- or 8-allylated or prenylated coumarins (2H-chromen-2-ones).

Synthesis and evaluation of the cytotoxicities of neoflavenes

The synthesis of neoflavene and neoflavenes with methoxy substituents at different positions are described. As starting materials, various salicylaldehydes were run through sequential reactions such as O-allylation, Grignard reaction, oxidation, Wittig reaction, and ring-closing metathesis to yield the target neoflavenes in good yield. Among the prepared neoflavenes, 7-methoxy-4′-methoxyneoflavene (6e) and 8-methoxy-4′- methoxyneoflavene (6f) exhibiting potential cell toxicities against various cells were disclosed. In particular, 6f which exhibited an IC50 value of 6.5 ± 2.0 and 5.1 ± 1.1 μM against gastric carcinoma and lung carcinoma cells in vitro was found, respectively. Meanwhile, the structure and activity relationship of our synthesized neoflavenes is further discussed briefly.

INTRAMOLECULAR ENE REACTION ON UNSATURATED THIOKETONES

The thermal cyclization of o-(2-substituted allyloxy)thiobenzophenones giving 1,5-oxathiocine derivatives is reported.This is the first example of the new type intramolecular ene reaction of unsaturated thioketones.