130804-19-2

Upstream product

• 111-68-2 1-Heptylamine 
• 4509-90-4 5-bromovaleroyl chloride 
• 130804-18-1 5-(4,5-diphenyl-1H-imidazol-2-ylthio)-pentanoic acid 

Downstream Products

• 136445-76-6 N-[5-(4,5-diphenyl-1H-imidazol-2-ylthio)pentyl]-1-heptanamine 
• 130804-35-2 N'-(2,4-difluorophenyl)-N-[5-(4,5-diphenyl-1H-imidazol-2-ylthio)pentyl]-N-heptylurea 

Relevant academic research and scientific papers

Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: Synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles

A series of 4,5-diaryl-2-(substituted thio)-1H-imidazoles has been synthesized and demonstrated to be potent inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). The design, synthesis, and structure-activity relationships for this series are reporte

Use of imidazoles for the treatment of atherosclerosis

This invention relates to imidazoles as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), processes for their preparation, and their use as antihypercholesterolemic agents or antiatherosclerotic. The compounds for use in the described method are