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13082-84-3

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13082-84-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 13082-84-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,0,8 and 2 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 13082-84:
(7*1)+(6*3)+(5*0)+(4*8)+(3*2)+(2*8)+(1*4)=83
83 % 10 = 3
So 13082-84-3 is a valid CAS Registry Number.

13082-84-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(5,6-dimethylbenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol

1.2 Other means of identification

Product number -
Other names 5,6-dimethyl-1-pentofuranosyl-1h-benzimidazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13082-84-3 SDS

13082-84-3Downstream Products

13082-84-3Relevant articles and documents

-

Davoll,Brown

, p. 5781 (1951)

-

Derivatives of 1-β-D-ribofuranosylbenzimidazole 3',5'-phosphate that mimic the actions of adenosine 3',5'-phosphate (cAMP) and guanosine 3',5'-phosphate (cGMP)

Genieser, Hans-Gottfried,Winkler, Elisabeth,Butt, Elke,Zorn, Michaela,Schulz, Susanne,et al.

, p. 217 - 236 (1992)

A series of new analogues of 1-β-D-ribofuranosylbenzimidazole 3',5'-phosphate (cBIMP) has been designed according to the properties predicted by the MNDO method, and synthesised from substituted benzimidazoles.Dipole vectors and HOMO and LUMO energies for each benzimidazole base were calculated by MNDO method and the lipophilicities of the cBIMP derivatives were determined.In general, the cBIMP derivatives activate cAMP-dependent protein kinases I and II and preferentially bind to site B, especially for the type II kinase, with 2-trifluoromethyl-cBIMP and 5,6-difluoro-cBIMP exhibiting the highest site selectivity.Each cBIMP derivative can stimulate cGMP-stimulated cyclic phosphodiesterase (cGS-PDE), with 5,6-dimethyl-cBIMP being as potent as cGMP, and also inhibit cGMP-inhibited phosphodiesterase (cGI-PDE).Only the 2-trifluoromethyl-cBIMP and the Rp-phosphorothioates (cBIMPS) (equatorial P=S) were resistant to hydrolysis by cPDE.The Sp-phosphorothioates were hydrolysed slowly, if at all.In addition to exhibiting a high lipophilicity, the most active compounds for the induction of apoptosis and inhibition of proliferation were also resistant to cPDE (Sp-5,6-dichloro-cBIMPS) and/or were potent activators of cAMP-dependent protein kinase (5,6-dichloro-cBIMP).

Deprotection of α-imidazole/benzimidazole ribonucleosides by catalytic carbon tetrabromide initiated photolysis

Chandra, Tilak,Brown, Kenneth L.

, p. 8617 - 8619 (2007/10/03)

Several protected benzimidazole and imidazole α-ribonucleosides were deprotected in excellent yield at ambient temperature using CBr4 initiated photolysis in methanol at ambient temperature. No selectivity was observed and both trityl and isopr

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