13083-62-0Relevant academic research and scientific papers
TRIALKYLSILANES AS SCAVENGERS FOR THE TRIFLUOROACETIC ACID DEBLOCKING OF PROTECTING GROUPS IN PEPTIDE SYNTHESIS
Pearson, Daniel A.,Blanchette, Mary,Baker, Mary Lou,Guindon, Cathy A.
, p. 2739 - 2742 (1989)
Triethylsilane was used as a scavenging agent in peptide synthesis for the removal of protecting groups with TFA.The efficiency of scavenging ability was compared with anisole and ethanedithiol in a kinetic experiment.It was also found that triethylsilane/TFA reduces the indole ring of tryptophan.
A New Reductive Modification of Hen's Egg White Lysozyme with Pyridine-borane
Kurata, Munetsugu,Kikugawa, Yasuo,Kuwae, Toyoyashu,Koyama, Iwao,Takagi, Tohru
, p. 2274 - 2275 (2007/10/02)
A reductive modification of tryptophan residues in hen's egg white lysozyme was carried out in trifluoroacetic acid with pyridine-borane.Six tryptophan residues were fully reduced to the corresponding 2,3-dihydro compounds without any detectable change in the molecule.Enzymic activities of the reduced lysozyme was found to be completely lost.
