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1308398-77-7

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((6-(((benzyloxy)carbonyl)amino)hexanoyl)oxy)-3-((tertbutoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((6-(((benzyloxy)carbonyl)amino)hexanoyl)oxy)-3-((tertbutoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

    Cas No: 1308398-77-7

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  • Binbo Biological Co., Ltd
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  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((6-(((benzyloxy)carbonyl)amino)hexanoyl)oxy)-3-((tertbutoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

    Cas No: 1308398-77-7

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  • Falcon Life Sciences Pvt. Ltd
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  • 1308398-77-7 Structure

  • Basic information

    1. Product Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((6-(((benzyloxy)carbonyl)amino)hexanoyl)oxy)-3-((tertbutoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
    2. Synonyms: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((6-(((benzyloxy)carbonyl)amino)hexanoyl)oxy)-3-((tertbutoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
    3. CAS NO:1308398-77-7
    4. Molecular Formula:
    5. Molecular Weight: 1083.24
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1308398-77-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((6-(((benzyloxy)carbonyl)amino)hexanoyl)oxy)-3-((tertbutoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((6-(((benzyloxy)carbonyl)amino)hexanoyl)oxy)-3-((tertbutoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate(1308398-77-7)
    11. EPA Substance Registry System: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((6-(((benzyloxy)carbonyl)amino)hexanoyl)oxy)-3-((tertbutoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate(1308398-77-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1308398-77-7(Hazardous Substances Data)

1308398-77-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1308398-77-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,8,3,9 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1308398-77:
(9*1)+(8*3)+(7*0)+(6*8)+(5*3)+(4*9)+(3*8)+(2*7)+(1*7)=177
177 % 10 = 7
So 1308398-77-7 is a valid CAS Registry Number.

1308398-77-7Downstream Products

1308398-77-7Relevant articles and documents

Discovery of a Novel Cabazitaxel Nanoparticle-Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects Using a β-Cyclodextrin-PEG Copolymer Based Delivery Platform

Metcalf, Chester A.,Svenson, Sonke,Hwang, Jungyeon,Tripathi, Snehlata,Gangal, Geeti,Kabir, Sujan,Lazarus, Douglas,Cole, Roderic,Sweryda-Krawiec, Beata,Shum, Pochi,Brown, Donna,Case, Roy I.,Van Der Poll, Derek,Rohde, Ellen,Harlfinger, Stephanie,Teng, Chi-Hse,Eliasof, Scott

, p. 9541 - 9559 (2019/11/11)

Novel nanoparticle-drug conjugates (NDCs) containing diverse, clinically relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were successfully generated and tested in drug discovery studies. The NDCs utilized structurally varied linkers that attached the drug payloads to a β-cyclodextrin-PEG copolymer to form self-assembled nanoparticles. In vitro release studies revealed a diversity of release rates driven by linker structure-activity relationships (SARs). Improved in vivo pharmacokinetics (PK) for the cabazitaxel (CBTX) NDCs with glycinate-containing (1c) and hexanoate-containing linkers (2c) were demonstrated, along with high and sustained tumor levels (>168 h of released drug in tumor tissues). This led to potent efficacy and survival in both taxane- and docetaxel-resistant in vivo anticancer mouse efficacy models. Overall, the CBTX-hexanoate NDC 2c (CRLX522), demonstrated optimal and improved in vivo PK (plasma and tumor) and efficacy profile versus those of the parent drug, and the results support the potential therapeutic use of CRLX522 as a new anticancer agent.

CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY

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Paragraph 1795, (2013/08/14)

Methods and compositions relating to CDP-taxane conjugates are described herein.

METHODS OF TREATING A SUBJECT AND RELATED PARTICLES, POLYMERS AND COMPOSITIONS

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Page/Page column 505-506, (2012/04/17)

Described herein are methods for treating a subject with combinations of polymer-agent particles and cyclodextrin polymer agent conjugates. The methods herein may be used to treat subjects identified with cancer, cardiovascular disorders, autoimmune disorders, or inflammatory disorders. Also described herein are compositions, dosage forms, and kits comprising polymer-agent particles and cyclodextrin polymer agent conjugates.

CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY

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Page/Page column 301-302, (2011/06/19)

Methods and compositions relating to CDP-taxane conjugates are described herein.

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