130848-96-3

Basic information

• Product Name: 1-amino-2-(3-trifluoromethylphenyl)ethylphosphonic acid
• CAS NO: 130848-96-3
• Molecular Weight: 269.16
• Mol File: 130848-96-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-amino-2-(3-trifluoromethylphenyl)ethylphosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-amino-2-(3-trifluoromethylphenyl)ethylphosphonic acid(130848-96-3)
• EPA Substance Registry System: 1-amino-2-(3-trifluoromethylphenyl)ethylphosphonic acid(130848-96-3)

Safety Data

• Hazardous Substances Data: 130848-96-3(Hazardous Substances Data)

Upstream product

• 401-79-6 1-methyl-3-trifluoromethyl-benzene 
• 2003-14-7 (3-trifluoromethyl-phenyl)-acetyl chloride 
• 402-23-3 1-bromomethyl-3-trifluoromethylbenzene 
• 130828-94-3 [1-{[1-Phenyl-meth-(E)-ylidene]-amino}-2-(3-trifluoromethyl-phenyl)-ethyl]-phosphonic acid diethyl ester 
• 130848-71-4 [1-Amino-2-(3-trifluoromethyl-phenyl)-ethyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Phosphonic acid analogs of fluorophenylalanines as inhibitors of human and porcine aminopeptidases N: Validation of the importance of the substitution of the aromatic ring

A library of phosphonic acid analogs of phenylalanine substituted with fluorine, chlorine and trifluoromethyl moieties on the aromatic ring was synthesized and evaluated for inhibitory activity against human (hAPN) and porcine (pAPN) aminopeptidases. Fluorogenic screening indicated that these analogs are micromolar or submicromolar inhibitors, both enzymes being more active against hAPN. In order to better understand the mode of the action of the most active compounds, molecular modeling was used. It confirmed that aminophosphonic portion of the enzyme is bound nearly identically in the case of all the studied compounds, whereas the difference in activity results from the placement of aromatic side chain of an inhibitor. Interestingly, both enantiomers of the individual compounds are usually bound quite similarly.